ArticlePLoS biology2011
Three distinct roles for notch in Drosophila R7 photoreceptor specification.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Sensory receptor expansion and neural accommodation in butterfly color vision.Science advances · 2026Article
- Sevenless: its function and structure in the specification of the Drosophila R7 photoreceptor.Genetics · 2026Review
- Decoding a Cell's Fate: How Notch and receptor tyrosine kinase signals specify the Drosophila R7 photoreceptor.Developmental biology · 2025Article
- Deep conservation complemented by novelty and innovation in the insect eye ground plan.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase.Molecular cell · 2024Article
- The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.Biology open · 2024Article
- PCP Auto Count: A Novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.bioRxiv : the preprint server for biology · 2024Article
- PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.Frontiers in cell and developmental biology · 2024Article
- Article
- Simplifying cell fate map by determining lineage history of core pathway activation during fate specification.Trends in developmental biology · 2022Article
- Semper's cells in the insect compound eye: Insights into ocular form and function.Developmental biology · 2021Review
- A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.PLoS genetics · 2020Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- The role of Sevenless in Drosophila R7 photoreceptor specification.Developmental biology · 2019Article
- TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.PLoS genetics · 2019Article
- IMP regulates Kuzbanian to control the timing of Notch signalling inDevelopment (Cambridge, England) · 2019Article
- TheDevelopment (Cambridge, England) · 2018Article
- Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye.PLoS genetics · 2018Article
- AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster.PLoS genetics · 2018Article
- Generation and Evolution of Neural Cell Types and Circuits: Insights from the Drosophila Visual System.Annual review of genetics · 2017Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Receptor tyrosine kinases (RTKs) and Notch (N) proteins are different types of transmembrane receptors that transduce extracellular signals and control cell fate. Here we examine cell fate specification in the Drosophila retina and ask how N acts together with the RTKs Sevenless (Sev) and the EGF receptor (DER) to specify the R7 photoreceptor. The retina is composed of many hundred ommatidia, each of which grows by recruiting surrounding, undifferentiated cells and directing them to particular fates. The R7 photoreceptor derives from a cohort of three cells that are incorporated together following specification of the R2-R5 and R8 photoreceptors. Two cells of the cohort are specified as the R1/6 photoreceptor type by DER activation. These cells then activate N in the third cell (the R7 precursor). By manipulation of N and RTK signaling in diverse combinations we establish three roles for N in specifying the R7 fate. The first role is to impose a block to photoreceptor differentiation; a block that DER activation cannot overcome. The second role, paradoxically, is to negate the first; Notch activation up-regulates Sev expression, enabling the presumptive R7 cell to receive an RTK signal from R8 that can override the block. The third role is to specify the cell as an R7 rather than an R1/6 once RTK signaling has specified the cells as a photoreceptor. We speculate why N acts both to block and to facilitate photoreceptor differentiation, and provide a model for how N and RTK signaling act combinatorially to specify the R1/6 and R7 photoreceptors as well as the surrounding non-neuronal cone cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.