ArticlePLoS biology2011
Tracing the trail of protons through complex I of the mitochondrial respiratory chain.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
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- Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis Patients: Insights from High-Resolution Respirometry.Biomedicines · 2024Article
- Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.Free radical biology & medicine · 2019Article
- Differential Mechanism of ATP Production Occurs in Response to Succinylacetone in Colon Cancer Cells.Molecules (Basel, Switzerland) · 2019Article
- A transcriptome analysis of the ameliorate effect of Cyclocarya paliurus triterpenoids on ethanol stress in Saccharomyces cerevisiae.World journal of microbiology & biotechnology · 2018Article
- Investigating the underlying mechanism of Saccharomyces cerevisiae in response to ethanol stress employing RNA-seq analysis.World journal of microbiology & biotechnology · 2017Article
- Mitochondrial determinants of mammalian longevity.Open biology · 2017Article
- Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice.PloS one · 2015Article
- Life-history Constraints on the Mechanisms that Control the Rate of ROS Production.Current genomics · 2014Article
- Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes.International journal of genomics · 2014Article
- Evolution of mitochondrial power in vertebrate metazoans.PloS one · 2014Article
- A computational model of reactive oxygen species and redox balance in cardiac mitochondria.Biophysical journal · 2013Article
- The role of mitochondrial DNA mutations and free radicals in disease and ageing.Journal of internal medicine · 2013Review
- Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria are the structures that produce the bulk part of the cellular energy currency ATP, which drives numerous energy requiring processes in the cell. This process involves a series of large enzyme complexes--the respiratory chain--that couples the transfer of electrons to the creation of a concentration gradient of protons across the inner mitochondrial membrane, which drives ATP synthesis. Complex I (or NADH-quinone oxidoreductase) is the largest and by far the most complicated of the respiratory chain enzyme complexes. The molecular mechanism whereby it couples electron transfer to proton extrusion has remained mysterious until very recently. Low-resolution X-ray structures of complex I have, surprisingly, suggested that electron transfer in the hydrophilic arm, protruding into the mitochondrial matrix, causes movement of a coupling rod that influences three putative proton pumps within the hydrophobic arm embedded in the inner mitochondrial membrane. In this Primer, we will briefly introduce the recent progress made in this area and highlight the road ahead that likely will unravel the detailed molecular mechanisms of complex I function.
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