ArticleCurrent genomics2011
Carcinoma of the Lower Uterine Segment (LUS): Clinicopathological Characteristics and Association with Lynch Syndrome.
Article in Current genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Endometrial Cancer of the Uterine Isthmus: A Cohort Study on Clinicopathological Features and Prognosis.Cancer medicine · 2026Article
- Large cervical endometrioid adenocarcinoma mimicking endometrial endometrioid adenocarcinoma: A case report.Radiology case reports · 2024Article
- Genomic determinants in advanced endometrial cancer patients with sustained response to hormonal therapy- case series and review of literature.Frontiers in oncology · 2023Article
- Advances in Research, Diagnosis, and Treatment of Neuroendocrine Cervical Carcinoma: A Review.Oncology reviews · 2023Review
- Neuroendocrine small cell carcinoma of the cervix: A case report.Molecular and clinical oncology · 2021Article
- Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade).International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2019Article
- The practice of universal screening for Lynch syndrome in newly diagnosed endometrial carcinoma.Health science reports · 2018Review
- Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors.Gynecologic oncology reports · 2018Article
- Clear cell carcinoma of the lower uterine segment: A case report.Molecular and clinical oncology · 2016Article
- The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.The application of clinical genetics · 2014Review
- Utility of MLH1 methylation analysis in the clinical evaluation of Lynch Syndrome in women with endometrial cancer.Current pharmaceutical design · 2014Article
- Relationship of lower uterine segment cancer with Lynch syndrome: a novel case with an hMLH1 germline mutation.Oncology reports · 2012Article
- Performance of PREMM(1,2,6), MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer cases.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer.Molecular biology international · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometrial cancer arises from the uterine body and fundus in many cases, but can also originate from the lower region of the uterine body through the upper region of the cervix. Such tumors are referred to as carcinoma of the lower uterine segment (LUS) or isthmus, and account for 3-6.3% of all cases of endometrial cancer. This relatively low incidence has permitted performance of only small-scale studies, but the clinical and pathological characteristics of carcinoma of the LUS in all these reports have differed from those of other endometrial cancers. Generally, endometrial cancer is classified into estrogen-dependent endometrioid adenocarcinoma (designated as type I), and non-endometrioid types that are less associated with estrogen and include poorly differentiated adenocarcinoma (type II). In some reports, carcinoma of the LUS has been found to have type II characteristics. Carcinoma of the LUS has also been associated with Lynch syndrome, a hereditary disease with frequent development of colorectal, endometrial, and ovarian cancers. Lynch syndrome is thought to be induced by mismatch repair gene mutation. The frequency of Lynch syndrome in cases of general endometrial cancer is 1-2%. In contrast, the frequency in patients with carcinoma of the LUS is much higher, with up to 29% of cases diagnosable with Lynch syndrome and a high frequency of hMSH2 mutation found in one study. This suggests that further investigation of the clinical and pathological characteristics of carcinoma of the LUS and the association with Lynch syndrome is required through performance of a large-scale survey.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.