ArticleNature2011
Human metabolic individuality in biomedical and pharmaceutical research.
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Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 564 papers, 13 of them syntheses that pooled it.
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564citing papers in PubMed, 13 pooled it
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Who cites it
564 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Use of Mendelian Randomization to Unveil Metabolic Markers inJournal of Korean medical science · 2026Pooled it
- A bibliometric and text-mining analysis of lipidomics and metabolomics in human disease.Frontiers in physiology · 2026Pooled it
- Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites.Cell genomics · 2025Pooled it
- Genome-wide association study and meta-analysis of phytosterols identifies a novel locus for serum levels of campesterol.Human genomics · 2024Pooled it
- Causal relationships of metabolites with allergic diseases: a trans-ethnic Mendelian randomization study.Respiratory research · 2024Pooled it
- Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis.Biomolecules · 2024Pooled it
- Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies.Cardiovascular research · 2023Pooled it
- Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study.Scientific reports · 2023Pooled it
- Individual participant data meta-analysis of metabolomics on sustained knee pain in primary osteoarthritis patients.Rheumatology (Oxford, England) · 2023Pooled it
- Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.Nature communications · 2022Pooled it
- Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study.Kidney international · 2022Pooled it
- Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.Nature communications · 2021Pooled it
- Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.Circulation research · 2022Trial
- Trial
- Trial
- Gene-Environment Interaction Mendelian Randomization Reveals Statin-Dependent Associations Between Metabolites and Lipid Traits.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Genotype-Dependent Effects of Mechanical Stretch and GATA4-Targeted Compound 3i-1262 in Cardiomyopathy Patient-Derived hiPSC-Cardiomyocytes.Basic & clinical pharmacology & toxicology · 2026Article
- Endogenous Biomarkers to Evaluate Transporter-Mediated Drug-Drug Interactions: Current Evidence, Impact on Clinical Pharmacology Strategy, Remaining Gaps, and Future Directions.Journal of clinical pharmacology · 2026Review
- Serum metabolic signatures associated with maximal voluntary ventilation in native high-altitude Tibetans.Metabolomics : Official journal of the Metabolomic Society · 2026Article
504 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors.
Karsten SuhreInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
So-Youn Shin *The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton UK.
Ann-Kristin Petersen *Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Robert P MohneyMetabolon Inc., Durham, North Carolina, USA.
David MeredithSchool of Life Sciences, Oxford Brookes University, Headington, Oxford, UK.
Brigitte WägeleInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Elisabeth AltmaierInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
CARDIoGRAM
Panos DeloukasThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton UK.
Jeanette ErdmannUniversität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.
Elin GrundbergThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton UK.
Christopher J HammondDepartment of Twin Research & Genetic Epidemiology, King's College London, UK.
Martin Hrabé de AngelisInstitute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Gabi KastenmüllerInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Anna KöttgenRenal Division, University Hospital Freiburg, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.
Massimo ManginoDepartment of Twin Research & Genetic Epidemiology, King's College London, UK.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Hans-Werner MewesInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Michael V MilburnMetabolon Inc., Durham, North Carolina, USA.
Cornelia PrehnInstitute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Johannes RafflerInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Janina S RiedThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton UK.
Werner Römisch-MarglInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, and Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK.
Kerrin S SmallDepartment of Twin Research & Genetic Epidemiology, King's College London, UK.
H-Erich WichmannInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Guangju ZhaiDepartment of Twin Research & Genetic Epidemiology, King's College London, UK.
Thomas IlligUnit for Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, UK.
Jerzy AdamskiInstitute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nicole Soranzo *The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton UK.
Christian Gieger *Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Funding
Regression of Atherosclerosis CoreP01HL098055 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FISHER, EDWARD A · 2010 to 2014
$12.1MREGULATION OF MONOCYTE 15-LIPOXYGENASE EXPRESSIONP01HL087018 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MCINTYRE, THOMAS M · 2007 to 2011
$11.4MA Genome-wide Association Study for Early-Onset Myocardial InfarctionR01HL087676 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ALTSHULER, DAVID · 2007 to 2009
$4.7MWhole Genome Association for Early Coronary Artery Disease and Related PhenotypesR01HL087647 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2006 to 2008
$4.6MBiomarkers for Complications in Type 1 Diabetes (DCCT/EDIC)R01DK080732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2009 to 2010
$1.4MCOMMUNITY AND COHORT SURVEILLANCE PROGRAMS-N01HC55015N01HC055015 · HC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CHAMBLESS, LLOYD E · 1985 to 2006
$1.1MCOMMUNITY AND COHORT SURVEILLANCE PROGRAMN01HC055016 · HC · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE M · 1985 to 2000
$785kFIELD CENTER FOR CCSPN01HC055019 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1985 to 2000
$748kFIELD CENTERN01HC055021 · HC · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI JONES, DANIEL W · 1985 to 2000
$617kCCSP-FIELD CENTERN01HC055020 · HC · JOHNS HOPKINS UNIVERSITY · PI NIETO, F JAVIER · 1985 to 2000
$334kCENTRAL HEMOSTATIS LABORATORY FOR CCSPN01HC055022 · HC · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, KENNETH K · 1985 to 2000
$264kCCSP--FIELD CENTER AND ULTRASOUND READING CENTERN01HC055018 · HC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI HEISS, GERARDO · 1985 to 2000
$104kBiotechnology and Biological Sciences Research CouncilBritish Heart FoundationCancer Research UKCIHR MOP172605CIHR MOP77682CIHR MOP‐82810Intramural NIH HHSMedical Research CouncilNHLBI NIH HHS 1R01HL103931‐01NHLBI NIH HHS HL087647NHLBI NIH HHS N01‐HC‐55015NHLBI NIH HHS N01‐HC‐55016NHLBI NIH HHS N01‐HC‐55018NHLBI NIH HHS N01‐HC‐55019NHLBI NIH HHS N01‐HC‐55020NHLBI NIH HHS N01‐HC‐55021NHLBI NIH HHS N01‐HC‐55022NHLBI NIH HHS P01HL076491‐06NHLBI NIH HHS P01HL087018NHLBI NIH HHS P01 HL098055NHLBI NIH HHS R01 HL087676NHLBI NIH HHS R01HL089650‐02NIA NIH HHS N01‐AG‐12100NIDDK NIH HHS R01DK080732Wellcome Trust 091746Wellcome Trust 091746/Z/10/Z
Abstract
Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking. Associations with metabolic traits as functional intermediates can overcome these problems and potentially inform individualized therapy. Here we report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences in metabolite levels per allele copy. Our associations provide new functional insights for many disease-related associations that have been reported in previous studies, including those for cardiovascular and kidney disorders, type 2 diabetes, cancer, gout, venous thromboembolism and Crohn's disease. The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research.
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Biomedical ResearchDrug IndustryGenetic VariationGenome-Wide Association StudyAdolescentAdultAgedAged, 80 and overBloodChildChronic DiseaseCoronary Artery DiseaseDiabetes MellitusFemaleGenetic LociGenotype
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.