ArticleNature protocols2011
Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice.
Article in Nature protocols, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 73 citations in OpenAlex.
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- Surgical polarimetric endoscopy for the detection of laryngeal cancer.Nature biomedical engineering · 2023Article
- Confocal Endomicroscopy Monitoring of Tumor Formation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy.Nature communications · 2022Article
- An "expressionistic" look at serrated precancerous colorectal lesions.Diagnostic pathology · 2021Article
- Machine Learning-Based Classification of the Health State of Mice Colon in Cancer Study from Confocal Laser Endomicroscopy.Scientific reports · 2019Article
- Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging.Journal of biomedical optics · 2019Article
- Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.Nature protocols · 2018Article
- Article
- Simultaneous Detection of EGFR and VEGF in Colorectal Cancer using Fluorescence-Raman Endoscopy.Scientific reports · 2017Article
- Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers.The Journal of investigative dermatology · 2017Review
- Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in Apc(min716/+) mice.Cancer medicine · 2016Article
- Diagnostic imaging advances in murine models of colitis.World journal of gastroenterology · 2016Review
- In-vivo monitoring of acute DSS-Colitis using Colonoscopy, high resolution Ultrasound and bench-top Magnetic Resonance Imaging in Mice.European radiology · 2015Article
- Near-Infrared Confocal Laser Endomicroscopy Detects Colorectal Cancer via an Integrin αvβ 3 Optical Probe.Molecular imaging and biology · 2015Article
- Confocal laser endomicroscopy to monitor the colonic mucosa of mice.Journal of immunological methods · 2015Article
- Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics.Scientific reports · 2015Article
- Needle-based fluorescence endomicroscopy via structured illumination with a plastic, achromatic objective.Journal of biomedical optics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New endoscopic techniques such as narrow-band imaging (NBI) and confocal laser endomicroscopy (CLE) have improved the in vivo diagnosis of human gastrointestinal diseases in the colon. Whereas NBI may facilitate the identification of neoplastic lesions, CLE permits real-time histology of the inflamed or neoplastic colonic mucosa through the use of fluorescent dyes. These techniques have been recently adopted for use during ongoing endoscopy in mice. This protocol, which can be completed in 2 h, provides a detailed description of NBI and CLE in the mouse colon. In contrast to other techniques, this approach does not require laparotomy, and it allows direct CLE analysis of lesions identified by NBI. Mice exposed to models of colitis or colorectal cancer are anesthetized and examined with a miniaturized NBI endoscope, which provides an increased contrast of the vasculature. Upon identification of suspicious areas by NBI and the administration of fluorescent dyes, a confocal laser probe can be directed to the area of interest through the endoscope and confocal images can be obtained. Through the use of various fluorescent dyes, different aspects of the mucosa can be assessed. In addition, fluorescence-labeled antibodies can be used for molecular imaging of mice in vivo. Mouse NBI endoscopy and CLE represent reliable and fast high-quality techniques for the endoscopic characterization and molecular imaging of the mucosa in colitis and colon cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.