ArticleScience (New York, N.Y.)2011
A gustotopic map of taste qualities in the mammalian brain.
Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
182 citing papers in PubMed, 1 synthesis or guideline pooled it, 391 citations in OpenAlex.
- Empirical assessment of changing sample-characteristics in task-fMRI over two decades: An example from gustatory and food studies.Human brain mapping · 2020Pooled it
- Effects of selective adaptation on coding sugar and salt tastes in mixtures.Chemical senses · 2012Trial
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Molecular architecture of excitatory and inhibitory neurons in the first gustatory relay.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- L-proline supplementation affects non-volatile flavour perception through oral microbiome metabolic pathways.NPJ science of food · 2025Article
- Article
- Article
- Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025Review
- Exogenous oral application of PYY and exendin-4 impacts upon taste-related behavior and taste perception in wild-type mice.Neuropharmacology · 2025Article
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Shapley Fields Reveal Chemotopic Organization in the Mouse Olfactory Bulb Across Diverse Chemical Feature Sets.bioRxiv : the preprint server for biology · 2025Article
- Neural Processing of Taste-Related Signals in the Mediodorsal Thalamus of Mice.bioRxiv : the preprint server for biology · 2025Article
- Cortical coding of gustatory and thermal signals in active licking mice.The Journal of physiology · 2025Article
- Potential role of glucagon like peptide 1 in taste receptors.Frontiers in endocrinology · 2025Review
- Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025Review
- Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.Frontiers in cell and developmental biology · 2025Review
- Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice.bioRxiv : the preprint server for biology · 2024Article
- The Insular Cortex: An Interface Between Sensation, Emotion and Cognition.Neuroscience bulletin · 2024Review
122 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The taste system is one of our fundamental senses, responsible for detecting and responding to sweet, bitter, umami, salty, and sour stimuli. In the tongue, the five basic tastes are mediated by separate classes of taste receptor cells each finely tuned to a single taste quality. We explored the logic of taste coding in the brain by examining how sweet, bitter, umami, and salty qualities are represented in the primary taste cortex of mice. We used in vivo two-photon calcium imaging to demonstrate topographic segregation in the functional architecture of the gustatory cortex. Each taste quality is represented in its own separate cortical field, revealing the existence of a gustotopic map in the brain. These results expose the basic logic for the central representation of taste.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.