Evidence map›Paper›PMID 21885598›Full record

ReviewCold Spring Harbor perspectives in biology2011

Integrins in cell migration.

Anna Huttenlocher, Alan Rick Horwitz

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 420 papers.

0numbers the graph read from it
0cells of the map it votes in
420citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

420 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Single-cell insights: Mosquito Toll activation enhances granulocyte differentiation and immune surveillance via Notch suppression.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Defining the role of integrins in melanoblast migrationMolecular biology of the cell · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Compressed Cells Facilitate Adhesion Through Glycocalyx.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  20. Integrin signaling pathways in mesenchymal stem cells.Stem cell research & therapy · 2025
    Review

360 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anna HuttenlocherDepartments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wsconsin 53706, USA.
Alan Rick Horwitz

Funding

STRUCTUREU54GM064346 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI IMPERIALI, BARBARA · 2001 to 2010
$74.9M
ADHESIVE REGULATION DURING CELL MIGRATIONR01CA085862 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2000 to 2026
$7.3M
DETERMINANTS OF MYOGENIC MEMBRANE PHENOMENAR01GM023244 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HORWITZ, ALAN F. "RICK" · 1985 to 2014
$6.7M
DETERMINANTS OF MYOGENIC MEMBRANE PHENOMENAR37GM023244 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HORWITZ, ALAN F · 1992 to 2002
$1.1M
NCI NIH HHS CA085862-08NCI NIH HHS R01 CA085862NIGMS NIH HHS GM23244NIGMS NIH HHS R01 GM023244NIGMS NIH HHS R37 GM023244NIGMS NIH HHS U54 GM064346NIGMS NIH HHS U54-GM064346
6 · The paper itself

Abstract

Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling complexes that regulate migration and the interplay among adhesion, signaling, and pliability of the substratum. Finally, we address mechanisms of adhesion assembly and disassembly and the role of adhesion in cellular polarity.

Indexed as

Models, BiologicalCell MovementCell PolarityFocal AdhesionsIntegrinsSignal TransductionIntegrins

Identifiers

PMID21885598
PMCPMC3181029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.