SynthesisPsychiatric services (Washington, D.C.)2011
Substance use disorder among people with first-episode psychosis: a systematic review of course and treatment.
Synthesis in Psychiatric services (Washington, D.C.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Association of Attention-Deficit/Hyperactivity Disorder in Childhood and Adolescence With the Risk of Subsequent Psychotic Disorder: A Systematic Review and Meta-analysis.JAMA psychiatry · 2021Pooled it
- Developing a Substance Use Practice Approach for Peer Support Specialists in Early Psychosis Coordinated Specialty Care.Early intervention in psychiatry · 2026Article
- Long-Acting Injectable Antipsychotics in Adolescents: From Current Evidence and Gaps to Clinical Practice.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Addressing the complex needs of homeless youth with early psychosis and comorbid substance use: a naturalistic longitudinal study of 10 years' experience with EQIIP SOL's specialized outreach service.Social psychiatry and psychiatric epidemiology · 2025Article
- Lived experience of gaming disorder among people with psychotic disorders: implications for tailored interventions and clinical management.Current opinion in psychiatry · 2025Review
- Falling Through the Cracks: Perspectives From Local Leaders on Substance Use and Psychosis Treatment for Youth.Journal of dual diagnosis · 2025Article
- Tobacco, Alcohol, and Drug Use Among Young Adults with Serious Mental Illness.Community mental health journal · 2024Article
- Remission with or without comorbid substance use disorders in early psychosis: long-term outcome in integrated care (ACCESS III study).Frontiers in psychology · 2023Article
- Family members' experiences of caring for a relative with substance-induced psychosis disorder.Curationis · 2022Article
- The association of cognitive impairment with quality of life and functional impairment in Ugandan first-episode psychosis patients: a cross sectional study.Health and quality of life outcomes · 2022Article
- An observational study of antipsychotic medication discontinuation in first-episode psychosis: clinical and functional outcomes.Social psychiatry and psychiatric epidemiology · 2022Observational
- Exploring protective associations between the use of classic psychedelics and cocaine use disorder: a population-based survey study.Scientific reports · 2022Article
- Clinical characterization of brief psychotic disorders triggered by the COVID-19 pandemic: a multicenter observational study.European archives of psychiatry and clinical neuroscience · 2022Observational
- "It's my frenemy": A qualitative exploration of knowledge and perceptions of fentanyl use during the COVID-19 pandemic in people who use drugs at a syringe services program in Philadelphia, PA.Frontiers in public health · 2022Article
- Impact of Substance Use Disorder on Between-Network Brain Connectivity in Early Psychosis.Schizophrenia bulletin open · 2022Article
- Barriers and Facilitators That Influence Providers' Ability to Educate, Monitor, and Treat Substance Use in First-Episode Psychosis Programs Using the Theoretical Domains Framework.Qualitative health research · 2021Article
- Cannabis use in patients with early psychosis is associated with alterations in putamen and thalamic shape.Human brain mapping · 2020Article
- Digital Health Around Clinical High Risk and First-Episode Psychosis.Current psychiatry reports · 2020Review
- A Retrospective Study of the Clinical Characteristics Associated with Alcohol and Cannabis use in Early Phase Psychosis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Societal Costs of Schizophrenia in Denmark: A Nationwide Matched Controlled Study of Patients and Spouses Before and After Initial Diagnosis.Schizophrenia bulletin · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePeople experiencing a first episode of psychosis frequently have co-occurring substance use disorders, usually involving alcohol and cannabis, which put them at risk for prolonged psychosis, psychotic relapse, and other adverse outcomes. Yet few studies of first-episode psychosis have addressed the course of substance use disorders and the response to specialized substance abuse treatments.
methodsThe authors searched MEDLINE, PsycINFO, and other medical databases for English-language articles published between 1990 and 2009. Included studies addressed two research questions. First, do some clients become abstinent after a first episode of psychosis without specialized substance abuse treatments? Second, for clients who continue to use substances after a first episode of psychosis, does the addition of specialized substance abuse treatment enhance outcomes?
resultsNine studies without specialized substance abuse treatment and five with specialized substance abuse treatment assessed the course of substance use (primarily cannabis and alcohol) after a first episode of psychosis. Many clients (approximately half) became abstinent or significantly reduced their alcohol and drug use after a first episode of psychosis. The few available studies of specialized substance abuse treatments did not find better rates of abstinence or reduction.
conclusionsExperience, education, treatment, or other factors led many clients to curtail their substance use disorders after a first episode of psychosis. Specialized interventions for others need to be developed and tested.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.