ArticleJournal of lipid research2011
Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions.
Article in Journal of lipid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 81 citations in OpenAlex.
- Cholesterol at the Center of Alzheimer's Disease: A Unifying Hypothesis on the Pathogenic Mechanism.Molecules (Basel, Switzerland) · 2026Review
- Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE.Drugs in context · 2025Article
- Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes.Journal of lipid research · 2022Article
- Comparative lipid profiling of murine and human atherosclerotic plaques using high-resolution MALDI MSI.Pflugers Archiv : European journal of physiology · 2022Article
- Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review.Frontiers in cell and developmental biology · 2021Review
- From Inert Storage to Biological Activity-In Search of Identity for Oxidized Cholesteryl Esters.Frontiers in endocrinology · 2020Review
- Data Processing Pipeline for Lipid Profiling of Carotid Atherosclerotic Plaque with Mass Spectrometry Imaging.Journal of the American Society for Mass Spectrometry · 2019Article
- Mass Spectrometric Imaging Reveals Temporal and Spatial Dynamics of Bioactive Lipids in Arteries Undergoing Restenosis.Journal of proteome research · 2019Article
- A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma.Journal of lipid research · 2019Article
- Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages.Redox biology · 2019Article
- Regulation and Functions of 15-Lipoxygenases in Human Macrophages.Frontiers in pharmacology · 2019Review
- Lipidomic insight into cardiovascular diseases.Biochemical and biophysical research communications · 2018Review
- Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.Circulation · 2018Review
- Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis.Frontiers in physiology · 2018Review
- Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.Nature cell biology · 2017Article
- Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease.Journal of lipid research · 2017Article
- Oxidized cholesteryl esters and inflammation.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Mass Spectrometric Collisional Activation and Product Ion Mobility of Human Serum Neutral Lipid Extracts.Analytical chemistry · 2016Article
- Article
- Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL.Current opinion in lipidology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although LDL is rendered proatherogenic by various experimental treatments (e.g., acetylation), the exact structural changes that drive LDL transformation in vivo remain enigmatic. Among the many hypothesized targets of oxidative modification are cholesterol esters (CE). This family of neutral lipids, which carries a highly unsaturated pool of fatty acyl groups, is the main component of both LDL particles and atherosclerotic plaques. Tandem mass spectrometry (MS/MS) was employed to reveal abundant and diverse oxidized CEs (oxCE), including novel oxidation products, within human peripheral vascular lesions. These oxCE species composed up to 40% of the total CE pool, with cholesteryl linoleate being oxidized to the greatest extent. Imaging mass spectrometry studies showed that oxCE was entirely confined within the plaque, along with unmodified CE and triacylglyceride (TAG). Interestingly, we found no evidence for TAG oxidation, although polyunsaturated species were abundant. Enzymatic oxidation of cholesteryl linoleate by 15-lipoxygenase (15-LO), an enzyme often invoked in CE oxidation, initially results in a regio- and stereospecific product. Analysis of intact cholesteryl hydroxyoctadecadienoate isomers in human atheromata revealed no regio- or stereospecificity, indicating 15-LO was either not a major source of oxCE or nonenzymatic processes had eroded any product specificity.
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Registered trials
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