ArticleCurrent biology : CB2011
Molecular organization of Drosophila neuroendocrine cells by Dimmed.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
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- Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression.Developmental neurobiology · 2022Article
- Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021Review
- Neuroendocrine neoplasia of the gastrointestinal tract revisited: towards precision medicine.Nature reviews. Endocrinology · 2020Review
- Different mechanisms for selective transport of fatty acids using a single class of lipoprotein inJournal of lipid research · 2019Article
- Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.PLoS genetics · 2017Article
- RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides.PLoS genetics · 2017Article
- A single transcription factor is sufficient to induce and maintain secretory cell architecture.Genes & development · 2017Article
- Transcriptional Reorganization ofFrontiers in molecular neuroscience · 2017Article
- TheFrontiers in molecular neuroscience · 2016Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- The Drosophila Prosecretory Transcription Factor dimmed Is Dynamically Regulated in Adult Enteroendocrine Cells and Protects Against Gram-Negative Infection.G3 (Bethesda, Md.) · 2015Article
- Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED.Nucleic acids research · 2015Article
- Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy.PloS one · 2015Article
- Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The Drosophila blood-brain barrier: development and function of a glial endothelium.Frontiers in neuroscience · 2014Review
- Pigment-dispersing factor modulates pheromone production in clock cells that influence mating in drosophila.Neuron · 2013Article
- Neuropeptides control life-phase transitions.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Insulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in Drosophila.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIn Drosophila, the basic-helix-loop-helix protein DIMM coordinates the molecular and cellular properties of all major neuroendocrine cells, irrespective of the secretory peptides they produce. When expressed by nonneuroendocrine neurons, DIMM confers the major properties of the regulated secretory pathway and converts such cells away from fast neurotransmission and toward a neuroendocrine state.
resultsWe first identified 134 transcripts upregulated by DIMM in embryos and then evaluated them systematically using diverse assays (including embryo in situ hybridization, in vivo chromatin immunoprecipitation, and cell-based transactivation assays). We conclude that of eleven strong candidates, six are strongly and directly controlled by DIMM in vivo. The six targets include several large dense-core vesicle (LDCV) proteins, but also proteins in non-LDCV compartments such as the RNA-associated protein Maelstrom. In addition, a functional in vivo assay, combining transgenic RNA interference with MS-based peptidomics, revealed that three DIMM targets are especially critical for its action. These include two well-established LDCV proteins, the amidation enzyme PHM and the ascorbate-regenerating electron transporter cytochrome b(561-1). The third key DIMM target, CAT-4 (CG13248), has not previously been associated with peptide neurosecretion-it encodes a putative cationic amino acid transporter, closely related to the Slimfast arginine transporter. Finally, we compared transcripts upregulated by DIMM with those normally enriched in DIMM neurons of the adult brain and found an intersection of 18 DIMM-regulated genes, which included all six direct DIMM targets.
conclusionsThe results provide a rigorous molecular framework with which to describe the fundamental regulatory organization of diverse neuroendocrine cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.