ArticleEpilepsy research2011
Importance of genetic factors in the occurrence of epilepsy syndrome type: a twin study.
Article in Epilepsy research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?Brain : a journal of neurology · 2014Trial
- Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.International journal of molecular sciences · 2024Review
- Review
- Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges.International journal of molecular sciences · 2023Review
- A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.Neuropathology and applied neurobiology · 2022Article
- [Twin research in Germany].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021Review
- Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2020Article
- Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings.Brain : a journal of neurology · 2019Observational
- Autism and social anxiety in children with sex chromosome trisomies: an observational study.Wellcome open research · 2019Article
- Epilepsy After Febrile Seizures: Twins Suggest Genetic Influence.Pediatric neurology · 2016Article
- Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Review
- Parental and comorbid epilepsy in persons with bipolar disorder.Journal of affective disorders · 2015Article
- [Evolution of electro clinical syndromes in dizygotic twins: from childhood to adolescence, about an observation].The Pan African medical journal · 2015Article
- The hidden genetics of epilepsy-a clinically important new paradigm.Nature reviews. Neurology · 2014Review
- Familial risk of epilepsy: a population-based study.Brain : a journal of neurology · 2014Article
- The role of T-type calcium channel genes in absence seizures.Frontiers in neurology · 2014Review
- Advances in epilepsy genetics and genomics.Epilepsy currents · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Although there is strong evidence that genetic factors contribute to risk for epilepsy, their role in the determination of syndrome type is less clear. This study was undertaken to address this question. Information related to epilepsy was obtained from twins included in 455 monozygotic and 868 dizygotic pairs ascertained from population-based twin registries in Denmark, Norway and the United States. Syndrome type was determined based on medical record information and detailed clinical interviews and classified using the International Classification Systems for the Epilepsies and Epileptic Syndromes. Concordance rates were significantly increased in monozygotic versus dizygotic pairs for all major syndrome groups except localization-related cryptogenic epilepsy. Among generalized epilepsies, genetic factors were found to play an important role in the determination of childhood absence, juvenile absence, juvenile myoclonic, and idiopathic generalized epilepsy; and to a lesser degree for epilepsies with grand mal seizures on awakening. Among localization-related epilepsies, genetic factors contributed to risk for localization-related idiopathic and symptomatic syndromes overall, but did not appear to play an important role in determining risk for frontal, occipital or temporal lobe epilepsy. These results suggest that, while genetic factors contribute to risk for major syndrome types, determined when possible, their contribution to risk for localization-related syndrome sub-types, as defined by specific focality, may be modest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.