ArticleMolecular cell2011
Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock.
Article in Molecular cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 126 citations in OpenAlex.
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- Molecular genetic examination of Circadian Clock Associated 1 gene (CCA1) in hexaploid wheat.BMC plant biology · 2026Article
- A circadian morning complex modulates far-red light signaling in Arabidopsis.Nature communications · 2025Article
- The PRR-EC complex and SWR1 chromatin remodeling complex function cooperatively to repress nighttime hypocotyl elongation by modulating PIF4 expression in Arabidopsis.Plant communications · 2024Article
- Evolution and Dynamic Transcriptome of Key Genes of Photoperiodic Flowering Pathway in Water Spinach (International journal of molecular sciences · 2024Article
- Review
- Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023Review
- Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9.Nature communications · 2022Article
- Variations in Circadian Clock Organization & Function: A Journey from Ancient to Recent.Planta · 2022Review
- Transcriptome analysis and phenotyping of walnut seedling roots under nitrogen stresses.Scientific reports · 2022Article
- Evolutionary Analysis and Functional Identification of Clock-AssociatedInternational journal of molecular sciences · 2022Article
- The circadian clock ticks in plant stress responses.Stress biology · 2022Review
- Mutations inFrontiers in plant science · 2022Article
- Regulation of flowering under short photoperiods based on transcriptomic and metabolomic analysis in Phaseolus vulgaris L.Molecular genetics and genomics : MGG · 2021Article
- Review
- Article
- Characterization ofFrontiers in plant science · 2021Article
- Article
- ABAS1 from soybean is a 1R-subtype MYB transcriptional repressor that enhances ABA sensitivity.Journal of experimental botany · 2020Article
- Light Perception: A Matter of Time.Molecular plant · 2020Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The COP10-DET1-DDB1 (CDD) complex is an evolutionarily conserved protein complex discovered for its role in the repression of photomorphogenesis in Arabidopsis. It is important in many cellular and developmental processes in both plants and animals, but its molecular mode of action remains poorly understood. Here, we show that the CDD component DET1 possesses transcriptional repression activity and physically interacts with two closely related MYB transcription factors, CCA1 and LHY, which are core components of the plant circadian clock. DET1 associates with the promoter of CCA1/LHY target genes, such as TOC1, in a CCA1/LHY-dependent manner and is required for their repression, suggesting a recruitment of DET1 by the central oscillator components to regulate the clock. Our results reveal DET1 as a core transcriptional repression factor important for clock progression. Overall, the CDD complex may function as a transcriptional corepressor in diverse processes through direct interaction with distinct transcription factors.
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