ArticleEvolution; international journal of organic evolution2011
Heterozygosity and its unexpected correlations with hybrid sterility.
Article in Evolution; international journal of organic evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Identification and genetic analysis of a pervasive 'needle-eye' sperm phenotype inProceedings. Biological sciences · 2024Article
- Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations.Molecular biology and evolution · 2022Article
- Article
- Coadapted genomes and selection on hybrids: Fisher's geometric model explains a variety of empirical patterns.Evolution letters · 2018Article
- Development of a Genomic Resource and Quantitative Trait Loci Mapping of Male Calling Traits in the Lesser Wax Moth, Achroia grisella.PloS one · 2016Article
- Hybrid male sterility between Drosophila willistoni species is caused by male failure to transfer sperm during copulation.BMC evolutionary biology · 2015Article
- Population structure and breeding value of a new type of Brassica juncea created by combining A and B genomes from related allotetraploids.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Experimental hybridization and backcrossing reveal forces of reproductive isolation in Microbotryum.BMC evolutionary biology · 2013Article
- Mechanistic basis of infertility of mouse intersubspecific hybrids.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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1 author.
Funding
Abstract
In general, heterozygosity is considered to be advantageous, primarily because it masks the effects of deleterious recessive alleles. However, there is usually a reduction in fitness in individuals that are heterozygous due to the pairing of two species (heterospecific). Because the parental alleles arose along separate evolutionary paths, they may not function properly when brought together within an individual. The formation of these unfit interspecies hybrids is one of the mechanisms that maintains species isolation. Interestingly, it has been observed that later-generation individuals resulting from a backcross to one parent are more often sterile than those resulting from a backcross to the other parent, but the mechanism underlying this trend is unknown. Here, I show that one direction of backcross produces offspring with more heterospecific genome, and that this is correlated with the directionality seen in backcross hybrid sterility. Therefore, the directionality in sterility is likely due to the different amounts of heterospecific genome present in the two backcrosses. Surprisingly, in spite of the potential fitness consequences, I also find that interspecies laboratory backcrosses in general yield an excess of heterospecific individuals, and that this trend is consistent across multiple taxa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.