Evidence map›Paper›PMID 21883999›Full record

ReviewCardiovascular therapeutics2012

TRITON and beyond: new insights into the profile of prasugrel.

Joseph A Jakubowski, Jeffrey S Riesmeyer, Sandra L Close, Amy G Leishman, David Erlinge

Abstract readReview
In one paragraph

Review in Cardiovascular therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Antiplatelet Therapy.Handbook of experimental pharmacology · 2026
    Review
  2. Article
  3. Personalized antiplatelet therapy with P2Y12 receptor inhibitors: benefits and pitfalls.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2015
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph A JakubowskiLilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. joseph@lilly.com
Jeffrey S Riesmeyer
Sandra L Close
Amy G Leishman
David Erlinge

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prasugrel, a third-generation thienopyridine antiplatelet agent, demonstrated superior efficacy to clopidogrel but with an increased risk of bleeding in the phase III pivotal registration Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction (TRITON-TIMI 38). This article reviews and discusses select components of a large literature of prasugrel data that has emerged since the TRITON-TIMI 38 (TRITON) study primary disclosure.

Indexed as

Acute Coronary SyndromeAngioplasty, Balloon, CoronaryDrug InteractionsDrug ResistanceEvidence-Based MedicineHemorrhageHumansMyocardial InfarctionPiperazinesPlatelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsThiophenesPiperazinesPlatelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsThiophenes

Identifiers

PMID21883999
PMCPMC3440581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.