ArticleMicrobial biotechnology2011
Growth phase-associated changes in the proteome and transcriptome of Lactobacillus rhamnosus GG in industrial-type whey medium.
Article in Microbial biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Growth Phase-Related DNA Methylation and Localized DNA Fragment Density Variation inEpigenomes · 2026Article
- Whey protein isolate enhances the growth and probiotic features of Lacticaseibacillus rhamnosus GG.Applied microbiology and biotechnology · 2026Article
- Lactic Acid Bacteria with Probiotic Potential Regulating Macrophages: Mechanisms, Regulatory Features, and Clinical Applications.Probiotics and antimicrobial proteins · 2026Review
- Milk Lipids as Bioactive Modulators of the Bacterial Proteome: Mechanisms Linking Dairy Management to Microbial Performance.Animals : an open access journal from MDPI · 2026Review
- Growth phase matters: Boosting immunity via Lacticasebacillus-derived membrane vesicles and their interactions with TLR2 pathways.Journal of extracellular biology · 2024Article
- Inorganic phosphate modifies stationary phase fitness and metabolic pathways inFrontiers in microbiology · 2024Article
- Evaluation of microbial communities of Chinese Feng-flavor Daqu with effects of environmental factors using traceability analysis.Scientific reports · 2023Article
- Transcriptomics ofFrontiers in bioengineering and biotechnology · 2023Article
- Sangyod rice bran extract enhancesVeterinary world · 2022Article
- The Gene Expression Profile Differs in Growth Phases of theMicroorganisms · 2022Article
- The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG.Applied microbiology and biotechnology · 2022Article
- Investigating Differential Expressed Genes ofFoods (Basel, Switzerland) · 2022Article
- Transcriptome analysis revealed growth phase-associated changes of a centenarian-originated probiotic Bifidobacterium animalis subsp. lactis A6.BMC microbiology · 2022Article
- Article
- Intestinal epithelial cell-derived components regulate transcriptome ofFrontiers in microbiology · 2022Article
- Transcriptome analysis of Lactobacillus rhamnosus GG strain treated with prebiotic - bovine lactoferrin under a cold environment.Journal of food and drug analysis · 2021Article
- Combined effect of arginine and fluoride on the growth of Lactobacillus rhamnosus GG.Scientific reports · 2021Article
- Integrated Transcriptome and Proteome Analyses Reveal Protein Metabolism inFrontiers in microbiology · 2021Article
- Ribosomal protein L4 of Lactobacillus rhamnosus LRB alters resistance to macrolides and other antibiotics.Molecular oral microbiology · 2020Article
- Effect of a novel synbiotic on Streptococcus mutans.Scientific reports · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growth phase during which probiotic bacteria are harvested and consumed can strongly influence their performance as health-promoting agents. In this study, global transcriptomic and proteomic changes were studied in the widely used probiotic Lactobacillus rhamnosus GG during growth in industrial-type whey medium under strictly defined bioreactor conditions. The expression of 636 genes (P ≤ 0.01) and 116 proteins (P < 0.05) changed significantly over time. Of the significantly differentially produced proteins, 61 were associated with alterations at the transcript level. The most remarkable growth phase-dependent changes occurred during the transition from the exponential to the stationary growth phase and were associated with the shift from glucose fermentation to galactose utilization and the transition from homolactic to mixed acid fermentation. Furthermore, several genes encoding proteins proposed to promote the survival and persistence of L. rhamnosus GG in the host and proteins that directly contribute to human health showed temporal changes in expression. Our results suggest that L. rhamnosus GG has a highly flexible and adaptable metabolism and that the growth stage during which bacterial cells are harvested and consumed should be taken into consideration to gain the maximal benefit from probiotic bacteria.
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