SynthesisInfluenza and other respiratory viruses2012
Performance of rapid influenza H1N1 diagnostic tests: a meta-analysis.
Synthesis in Influenza and other respiratory viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Double-Negative Results Matter: A Reevaluation of Sensitivities for Detecting SARS-CoV-2 Infection Using Saliva Versus Nasopharyngeal Swabs.American journal of epidemiology · 2024Pooled it
- Seasonal Influenza: A Narrative Review of Epidemiology, Clinical Features, and Preventive Strategies.Cureus · 2025Review
- Article
- Performance evaluation of influenza a rapid antigen test and PCR among nasopharyngeal and oropharyngeal samples.Practical laboratory medicine · 2024Article
- Taiwanese Guidelines for Molecular Point-of-Care Testing for Influenza in Emergency Medicine From the New Diagnostic Technology Team of the Taiwan Society of Emergency Medicine.Journal of acute medicine · 2023Article
- Influenza Myocarditis: A Literature Review.Cureus · 2020Review
- Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Rapid Antigen Tests for Influenza: Rationale and Significance of the FDA Reclassification.Journal of clinical microbiology · 2018Review
- The assessment of data sources for influenza virologic surveillance in New York State.Influenza and other respiratory viruses · 2017Article
- A Narrative Review of Influenza: A Seasonal and Pandemic Disease.Iranian journal of medical sciences · 2017Review
- Performance of the Quidel Sofia rapid influenza diagnostic test during the 2012-2013 and 2013-2014 influenza seasons.Influenza and other respiratory viruses · 2016Article
- An algorithm to diagnose influenza infection: evaluating the clinical importance and impact on hospital costs of screening with rapid antigen detection tests.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Can newly developed, rapid immunochromatographic antigen detection tests be reliably used for the laboratory diagnosis of influenza virus infections?Journal of clinical microbiology · 2015Article
- Performance of rapid influenza diagnostic tests (QuickVue) for influenza A and B Infection in India.Indian journal of medical microbiology · 2015Article
- New rapid diagnostic tests: a real improvement for clinical use?Journal of clinical microbiology · 2015Article
- Rapid diagnosis of influenza: state of the art.Clinics in laboratory medicine · 2014Review
- Comparing the use of, and considering the need for, lumbar puncture in children with influenza or other respiratory virus infections.Influenza and other respiratory viruses · 2013Article
- Article
- Comparison of Xpert Flu rapid nucleic acid testing with rapid antigen testing for the diagnosis of influenza A and B.Journal of virological methods · 2012Article
- Rapid influenza H1N1 diagnostic test: its diagnostic property.Influenza and other respiratory viruses · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundFollowing the outbreaks of 2009 pandemic H1N1 infection, rapid influenza diagnostic tests have been used to detect H1N1 infection. However, no meta-analysis has been undertaken to assess the diagnostic accuracy when this manuscript was drafted.
methodsThe literature was systematically searched to identify studies that reported the performance of rapid tests. Random effects meta-analyses were conducted to summarize the overall performance.
resultsSeventeen studies were selected with 1879 cases and 3477 non-cases. The overall sensitivity and specificity estimates of the rapid tests were 0·51 (95%CI: 0·41, 0·60) and 0·98 (95%CI: 0·94, 0·99). Studies reported heterogeneous sensitivity estimates, ranging from 0·11 to 0·88. If the prevalence was 30%, the overall positive and negative predictive values were 0·94 (95%CI: 0·85, 0·98) and 0·82 (95%CI: 0·79, 0·85). The overall specificities from different manufacturers were comparable, while there were some differences for the overall sensitivity estimates. BinaxNOW had a lower overall sensitivity of 0·39 (95%CI: 0·24, 0·57) compared with all the others (P-value <0·001), whereas QuickVue had a higher overall sensitivity of 0·57 (95%CI: 0·50, 0·63) compared with all the others (P-value = 0·005).
conclusionsRapid tests have high specificity but low sensitivity and thus limited usefulness.
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