ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2012
Modulation of hepatocyte growth factor secretion in human female reproductive tract stromal fibroblasts by poly (I:C) and estradiol.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Hepatocyte growth factor may contribute to male protection against pulmonary arterial hypertension.Biology of sex differences · 2026Article
- Ewe breed differences in the cervical transcriptome at the follicular phase of a synchronised oestrous cycle.BMC genomics · 2022Article
- The impact of aging on innate and adaptive immunity in the human female genital tract.Aging cell · 2021Review
- Estradiol-regulated innate antiviral responses of human endometrial stromal fibroblasts.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Poly (I:C) and LPS induce distinct immune responses by ovarian stromal fibroblasts.Journal of reproductive immunology · 2018Article
- The role of sex hormones in immune protection of the female reproductive tract.Nature reviews. Immunology · 2015Review
- The role of sex hormones and the tissue environment in immune protection against HIV in the female reproductive tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- The immune system in menopause: pros and cons of hormone therapy.The Journal of steroid biochemistry and molecular biology · 2014Review
- Restricted nutrient intake does not alter serum-mediated measures of implant response in cell culture.Journal of animal science and biotechnology · 2013Article
- Innate immunity in the vagina (part I): estradiol inhibits HBD2 and elafin secretion by human vaginal epithelial cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
- Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts.PloS one · 2013Article
- The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
problemHepatocyte Growth Factor (HGF) secretion facilitates epithelial cell growth and development in the female reproductive tract (FRT) and may contribute to pathological conditions such as cancer and endometriosis. We hypothesized that estradiol and poly (I:C), a synthetic RNA mimic, may have a regulatory effect on HGF secretion by stromal fibroblasts from FRT tissues. METHOD OF STUDY: Following hysterectomies, normal tissue from the uterus, endocervix, and ectocervix were dispersed into stromal cell fractions by enzymatic digestion and differential filtering. Stromal fibroblasts were cultured and treated with estradiol and/or poly (I:C), and conditioned media were analyzed for HGF via enzyme-linked immunosorbent assay.
resultsTreating uterine fibroblasts with estradiol or poly (I:C) significantly increased HGF secretion. When uterine fibroblasts were co-treated with estradiol and poly (I:C), the effect on HGF secretion was additive. In contrast, stromal fibroblasts from endo- and ecto-cervix were unresponsive to estradiol, but were stimulated to secrete HGF by poly (I:C).
conclusionHGF secretion is uniquely regulated in the uterus, but not in ecto- and endo-cervix, by estradiol. Moreover, potential viral pathogens further induce HGF. These findings have potential applications in understanding both hormonal regulation of normal tissue as well as the role of HGF in tumorogenesis, endometriosis, and human immunodeficiency virus infection.
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Registered trials
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