ArticleJournal of evolutionary biology2011
The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection.
Article in Journal of evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Disentangling Environmental and Within-Host Drivers of Parasite Dynamics in Natural Populations.Molecular ecology · 2026Article
- Co-infection with a viral pathogen (Theiler's murine encephalomyelitis virus) tended to improve host tolerance but significantly enhanced resistance to Heligmosomoides bakeri.Veterinary research communications · 2026Article
- Malaria parasites can optimize transmission investment by sensing two within-host cues.PLoS biology · 2025Article
- Dynamics of parasite growth in genetically diverse Plasmodium falciparum isolates.Molecular and biochemical parasitology · 2023Article
- Low Complexity of Infection Is Associated With Molecular Persistence ofFrontiers in epidemiology · 2022Article
- Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density.Malaria journal · 2021Article
- [Polymorphisms inThe Pan African medical journal · 2021Article
- Co-transmission of Related Malaria Parasite Lineages Shapes Within-Host Parasite Diversity.Cell host & microbe · 2020Article
- Evolutionary consequences of feedbacks between within-host competition and disease control.Evolution, medicine, and public health · 2020Article
- Elucidating cryptic dynamics ofEcology and evolution · 2020Article
- Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Within-host competition can delay evolution of drug resistance in malaria.PLoS biology · 2018Article
- Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance inInfectious Disease Modelling · 2017Article
- Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum.Proceedings. Biological sciences · 2016Article
- The potential impact of coinfection on antimicrobial chemotherapy and drug resistance.Trends in microbiology · 2015Review
- Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi.The American journal of tropical medicine and hygiene · 2015Article
- Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring.Evolutionary applications · 2015Article
- Is selection relevant in the evolutionary emergence of drug resistance?Trends in microbiology · 2015Review
- Malaria-induced changes in host odors enhance mosquito attraction.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Single-cell genomics for dissection of complex malaria infections.Genome research · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Malaria infections normally consist of more than one clonally replicating lineage. Within-host interactions between sensitive and resistant parasites can have profound effects on the evolution of drug resistance. Here, using the Plasmodium chabaudi mouse malaria model, we ask whether the costs and benefits of resistance are affected by the number of co-infecting strains competing with a resistant clone. We found strong competitive suppression of resistant parasites in untreated infections and marked competitive release following treatment. The magnitude of competitive suppression depended on competitor identity. However, there was no overall effect of the diversity of susceptible parasites on the extent of competitive suppression or release. If these findings generalize, then transmission intensity will impact on resistance evolution because of its effect on the frequency of mixed infections, not because of its effect on the distribution of clones per host. This would greatly simplify the computational problems of adequately capturing within-host ecology in models of drug resistance evolution in malaria.
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