ArticleJournal of the American Geriatrics Society2011
Measurement of organ structure and function enhances understanding of the physiological basis of frailty: the Cardiovascular Health Study.
Article in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Instruments for the detection of frailty syndrome in older adults: A systematic review.PloS one · 2019Pooled it
- The Association of Prior Intensive Lifestyle Intervention and Diabetes Support and Education With Frailty Prevalence at Long-Term Follow-Up in the Action for Health in Diabetes Extension Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population.Scientific reports · 2019Trial
- Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction Are Related to Worsening Healthy Aging Index and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Frailty and associated factors among older patients with non-dialysis chronic kidney disease: a multicenter cross-sectional study in three hospitals in Yaounde, Cameroon.The Pan African medical journal · 2025Article
- Development and internal validation of an age less-dependent frailty score in the cardiovascular health study.Frontiers in medicine · 2025Article
- Metabolomic characterization of vigor to frailty among community-dwelling older Black and White men and women.GeroScience · 2024Article
- Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates.Experimental gerontology · 2024Article
- Discordant Biological and Chronological Age: Implications for Cognitive Decline and Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- A Metabolite Composite Score Attenuated a Substantial Portion of the Higher Mortality Risk Associated With Frailty Among Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Quantifying and Classifying Physical Resilience Among Older Adults: The Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Principles and Issues for Physical Frailty Measurement and Its Clinical Application.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Frailty, MRI, and FDG-PET Measures in an Australian Memory Clinic Cohort.Frontiers in medicine · 2020Article
- Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men.Metabolites · 2019Article
- Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts.American journal of epidemiology · 2018Article
- Comparison of two frailty indices in the physicians' health study.Archives of gerontology and geriatrics · 2017Article
- Frailty, Aging, and Cardiovascular Surgery.Anesthesia and analgesia · 2017Review
- Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology.Journal of the American Geriatrics Society · 2016Article
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6 authors.
Funding
Abstract
objectivesTo determine whether disease burden is associated with frailty independent of diagnosed chronic disease and whether physiological measurements provide greater understanding of the etiology of frailty.
designCross-sectional.
settingCommunity.
participantsTwo thousand four hundred thirty-seven participants in the Cardiovascular Health Study, 1992/93 examination (mean age 74.8 ± 4.8, 43.4% male, 95.8% white). MEASUREMENTS: Disease burden and frailty were tabulated using 10-point scales (0 = healthy, 10 = unhealthy). Disease burden was the sum of measurements characterizing the vasculature, brain, kidneys, lungs, and glucose metabolism. Frailty was assessed using the frailty index reported by Fried. Multivariate linear models were used to determine the association between disease burden (predictor) and frailty (outcome).
resultsUnadjusted, 1-point-higher disease burden was associated with a 0.28-point-higher frailty score (P < .001). White matter grade, forced vital capacity, and cystatin-C were particularly strongly and significantly associated with frailty. Disease burden attenuated the association between frailty and age by 29%, and disease burden and age had similar associations with frailty. Disease burden attenuated the association between frailty and fibrinogen, Factor VIII, and C-reactive protein by 32%, 56%, and 83%, respectively. Frailty was associated with diagnosed depression, stroke, cognitive impairment, arthritis, and pulmonary disease but not coronary heart disease, diabetes mellitus, or kidney disease in the presence of a summary of disease burden. In the adjusted model, disease burden remained significantly associated with frailty (β = 0.11, P < .001).
conclusionDisease burden was independently and significantly associated with frailty. These results emphasize that typically unrecognized physiological changes may contribute significantly to frailty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.