ReviewTissue engineering. Part B, Reviews2012
Hair follicle regeneration in skin grafts: current concepts and future perspectives.
Review in Tissue engineering. Part B, Reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy of adipose-derived stem cells in burn injuries: a systematic review.Cellular & molecular biology letters · 2024Pooled it
- Biodegradable Temporizing Matrix for Facial Reconstruction Following Mohs Micrographic Surgery: A Multi-Subunit Analysis.Bioengineering (Basel, Switzerland) · 2026Article
- Scalp Reconstruction With a Synthetic Dermal Substitute After Cylindroma Excision in Brooke-Spiegler Syndrome.Plastic and reconstructive surgery. Global open · 2026Article
- Biological and mechanical influence of three-dimensional microenvironment formed in microwell on multicellular spheroids composed of heterogeneous hair follicle stem cells.Scientific reports · 2023Article
- Multilayered Gel-Spotting Device forMicromachines · 2023Article
- Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls.Bioengineering & translational medicine · 2022Review
- Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice.Journal of diabetes research · 2022Article
- PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration.Stem cell research & therapy · 2020Article
- Regeneration of skin appendages and nerves: current status and further challenges.Journal of translational medicine · 2020Review
- Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus.Neural regeneration research · 2016Article
- Rapid creation of skin substitutes from human skin cells and biomimetic nanofibers for acute full-thickness wound repair.Burns : journal of the International Society for Burn Injuries · 2015Article
- Tissue engineering in burn scar reconstruction.Burns & trauma · 2015Review
- Engineering functional epithelium for regenerative medicine and in vitro organ models: a review.Tissue engineering. Part B, Reviews · 2013Review
- Bioengineered skin substitutes: key elements and novel design for biomedical applications.International wound journal · 2013Review
- Current progress of skin tissue engineering: Seed cells, bioscaffolds, and construction strategies.Burns & trauma · 2013Article
- 25 years of epidermal stem cell research.The Journal of investigative dermatology · 2012Review
- Hair Growth Around the Scar. Potential Therapeutic Modality to Treat Alopecias?Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The repair and management of full-thickness skin defects resulting from burns and chronic wounds remain a significant unmet clinical challenge. For those skin defects exceeding 50%-60% of total body surface area, it is impractical to treat with autologous skin transplants because of the shortage of donor sites. The possibility of using tissue-engineered skin grafts for full-thickness wound repair is a promising approach. The primary goal of tissue-engineered skin grafts is to restore lost barrier function, but regeneration of appendages, such as hair follicles, has to be yet achieved. The successful regeneration of hair follicles in immunodeficient mice suggests that creating human hair follicles in tissue-engineered skin grafts is feasible. However, many limitations still need to be explored, particularly enriching isolated cells with trichogenic capacity, maintaining this ability during processing, and providing the cells with proper environmental cues. Current advances in hair follicle regeneration, in vitro and in vivo, are concisely summarized in this report, and key requirements to bioengineer a hair follicle are proposed, with emphasis on a three-dimensional approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.