ArticleEcotoxicology (London, England)2012
Histologic, immunologic and endocrine biomarkers indicate contaminant effects in fishes of the Ashtabula River.
Article in Ecotoxicology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Novel Adomaviruses Associated with Blotchy Bass Syndrome in Black Basses (bioRxiv : the preprint server for biology · 2025Article
- Novel adomaviruses associated with blotchy bass syndrome in black basses (Micropterus spp.).PloS one · 2025Article
- Assessing Fish Immunotoxicity by Means ofFrontiers in immunology · 2022Review
- Tissue Distribution and Immunomodulation in Channel Catfish (International journal of environmental research and public health · 2020Article
- Micronuclei and other erythrocyte nuclear abnormalities in fishes from the Great Lakes Basin, USA.Environmental and molecular mutagenesis · 2017Article
- Polish Scientists in Fish Immunology: A Short History.Biology · 2015Review
- Metabolic enzymes activity and histomorphology in the liver of whitefish (Coregonus lavaretus L.) and pike (Esox lucius L.) inhabiting a mineral contaminated lake.Environmental science and pollution research international · 2014Article
- Distribution and ecological risk assessment of organochlorine pesticides in sediments from four lakes of Heilongjiang Province, China.Ecotoxicology (London, England) · 2014Article
- Histopathological and ultrastructural perturbations in tilapia liver as potential indicators of pollution in Lake Al-Asfar, Saudi Arabia.Environmental science and pollution research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of fish as sentinels of aquatic ecosystem health is a biologically relevant approach to environmental monitoring and assessment. We examined the health of the Ashtabula River using histologic, immunologic, and endocrine biomarkers in brown bullhead (BB; Ameiurus nebulosus) and largemouth bass (Micropterus salmoides) and compared fish collected from a reference site (Conneaut Creek). Seasonal analysis was necessary to distinguish differences in fish between the two rivers. Overall BB from the Ashtabula River had a lower condition factor and significantly more macrophage aggregates than those from the reference site. Reduced bactericidal and cytotoxic-cell activity was observed in anterior kidney leukocytes from both BB and largemouth bass from the Ashtabula River. Lower plasma thyroxine and triiodo-L-thyronine in both species in the Ashtabula River indicated disruption of the thyroid axis. Differences in physiological biomarker responses were supported by body burden chemical concentrations when data were analyzed on a seasonal basis. The use of two fish species added a level of rigor that demonstrated biological effects were not exclusive to a single species. The results provide strong evidence that contaminants have affected fish in the Ashtabula River, a Great Lakes Area of Concern, and provide a baseline by which to evaluate remediation activities.
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Registered trials
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