ArticleJournal of assisted reproduction and genetics2011
Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection.
Article in Journal of assisted reproduction and genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Spindle-to-oocyte light retardance ratio as a noninvasive biomarker for oocyte quality assessment: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Low-air-pressure clean room system: A flexible, high-quality model for assisted reproduction laboratories.Clinical and experimental reproductive medicine · 2025Article
- Vitrification of Human Oocytes Before or After Rescue-IVM Does not Impair Maturation Kinetics but Induces Meiotic Spindle Alterations.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.Biology of reproduction · 2020Article
- Time-lapse monitoring of mouse embryos produced by injecting sonicated, frozen-thawed sperm heads with high or low chromosomal integrity.Reproductive medicine and biology · 2020Article
- Combined noninvasive metabolic and spindle imaging as potential tools for embryo and oocyte assessment.Human reproduction (Oxford, England) · 2019Article
- Meiotic spindle size is a strong indicator of human oocyte quality.Reproductive medicine and biology · 2018Article
- Relationship between meiotic spindles visualization and intracytoplasmic sperm injection outcomes in human oocytes.Anatomy & cell biology · 2017Article
- Erroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination.Biophysical journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection (ICSI).
methodsZygotes that had cleaved to two-cell stage by 27 h post-ICSI were classified as early cleaving and the remainder as late cleaving. Meiotic spindle parameters previously imaged using the PolScope were compared between the two groups.
resultsOf 384 embryos, 163 were classed as early cleaving and 221 as late cleaving. The rate of blastocyst formation or pregnancy by Day 2 embryo transfer was significantly higher following early cleavage than after late cleavage (52.4% vs. 24.4% or 32.6% vs. 11.4%). Spindle areas (108.0 vs. 89.8 μm(2)), lengths (14.7 vs. 13.4 μm) and PolScope retardance were also significantly greater in the early cleaving group.
conclusionsMeiotic spindle parameters determine the timing of the first zygotic cleavage and are strong indicators of human embryo developmental potential.
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Registered trials
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