ArticleEnvironmental health and preventive medicine2012
Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: a cohort study in Medawachchiya, Sri Lanka.
Article in Environmental health and preventive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Heterogeneity in diagnostic criteria for chronic kidney disease of undetermined etiology (CKDu): a systematic review of the literature.BMC nephrology · 2025Pooled it
- Chronic kidney disease of unknown etiology in Sri Lanka.International journal of occupational and environmental health · 2016Pooled it
- Escalating chronic kidney diseases of multi-factorial origin in Sri Lanka: causes, solutions, and recommendations.Environmental health and preventive medicine · 2014Pooled it
- A retrospective study of CKDu progression in Sri Lanka: analysis of kidney biopsies and association with risk factors.BMC nephrology · 2026Article
- A Whole-Exome Sequencing-Based Exploration of Chronic Kidney Disease of Unknown Etiology (CKDu) in an Endemic Population in Sri Lanka.International journal of molecular sciences · 2026Article
- Prevalence of Chronic Kidney Disease and Associated Factors among the Diabetic and Prediabetic Population in the Bandare-Kong Cohort Study; A Population-Based Study.Archives of Iranian medicine · 2024Article
- Urinary biomarkers indicate pediatric renal injury among rural farming communities in Sri Lanka.Scientific reports · 2022Article
- Inflammation-Related Factors Identified as Biomarkers of Dehydration and Subsequent Acute Kidney Injury in Agricultural Workers.Biological research for nursing · 2021Article
- Article
- Does fluoride cause the mysterious chronic kidney disease of multifactorial origin?Environmental geochemistry and health · 2020Review
- Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka.International journal of environmental research and public health · 2020Article
- Chronic Kidney Disease among Diabetes Patients in Ethiopia: A Systematic Review and Meta-Analysis.International journal of nephrology · 2020Review
- Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology.International journal of nephrology and renovascular disease · 2020Review
- Article
- Kidney progression project (KiPP): Protocol for a longitudinal cohort study of progression in chronic kidney disease of unknown etiology in Sri Lanka.Global public health · 2019Article
- Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study.The Journal of the Egyptian Public Health Association · 2019Article
- Early renal damage among children living in the region of highest burden of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka.BMC nephrology · 2018Article
- Kidney Diseases in Agricultural Communities: A Case Against Heat-Stress Nephropathy.Kidney international reports · 2018Review
- Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study.BMC nephrology · 2017Article
- Quest to identify geochemical risk factors associated with chronic kidney disease of unknown etiology (CKDu) in an endemic region of Sri Lanka-a multimedia laboratory analysis of biological, food, and environmental samples.Environmental monitoring and assessment · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe alarming rise in the prevalence of chronic kidney disease of uncertain etiology (CKDu) among the low socioeconomic farming community in the North Central Province of Sri Lanka has been recognized as an emerging public health issue in the country.
methodsThis study sought to determine the possible factors associated with the progression and mortality of CKDu. The study utilized a single-center cohort registered in 2003 and followed up until 2009 in a regional clinic in the endemic region, and used a Cox proportional hazards model.
resultsWe repeatedly found an association between disease progression and hypertension. Men were at higher risk of CKDu than women. A significant proportion of the patients in this cohort were underweight, which emphasized the need for future studies on the nutritional status of these patients.
conclusionsCompared with findings in western countries and other regions of Asia, we identified hypertension as a major risk factor for progression of CKDu in this cohort.
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