ArticleImmunogenetics2012
Diversity of MHC class I haplotypes in cynomolgus macaques.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Dynamic evolution of Mhc haplotypes in cynomolgus macaques of different geographic origins.Immunogenetics · 2022Article
- Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus.NPJ vaccines · 2021Article
- Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer.Immunogenetics · 2021Article
- CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts.Journal of virology · 2021Article
- Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species.Immunogenetics · 2020Article
- Review
- Article
- MHC class I diversity of olive baboons (Papio anubis) unravelled by next-generation sequencing.Immunogenetics · 2018Article
- Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Diversity of ULBP5 in Old-World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Article
- Major histocompatibility complex haplotyping and long-amplicon allele discovery in cynomolgus macaques from Chinese breeding facilities.Immunogenetics · 2017Article
- Comparative genomics of the human, macaque and mouse major histocompatibility complex.Immunology · 2017Review
- Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina).Immunogenetics · 2016Article
- Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques.Immunogenetics · 2014Article
- Identification of MHC class I sequences in four species of Macaca of China.Immunogenetics · 2013Article
- Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.Immunogenetics · 2013Article
- Challenges and approaches for the development of safer immunomodulatory biologics.Nature reviews. Drug discovery · 2013Review
- Natural selection on marine carnivores elaborated a diverse family of classical MHC class I genes exhibiting haplotypic gene content variation and allelic polymorphism.Immunogenetics · 2012Article
- Multilocus definition of MHC haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).Immunogenetics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cynomolgus macaques are widely used as a primate model for human diseases associated with an immunological process. Because there are individual differences in immune responsiveness, which are controlled by the polymorphic nature of the major histocompatibility (MHC) locus, it is important to reveal the diversity of MHC in the model animal. In this study, we analyzed 26 cynomolgus macaques from five families for MHC class I genes. We identified 32 Mafa-A, 46 Mafa-B, 6 Mafa-I, and 3 Mafa-AG alleles in which 14, 20, 3, and 3 alleles were novel. There were 23 MHC class I haplotypes and each haplotype was composed of one to three Mafa-A alleles and one to five Mafa-B alleles. Family studies revealed that there were two haplotypes which contained two Mafa-A1 alleles. These observations demonstrated further the complexity of MHC class I locus in the Old World monkey.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.