Evidence map›Paper›PMID 21881914›Full record

ArticleNeuroradiology2012

Pipeline embolization device (PED) for neurovascular reconstruction: initial experience in the treatment of 101 intracranial aneurysms and dissections.

Sebastian Fischer, Zsolt Vajda, Marta Aguilar Perez, Elisabeth Schmid, Nikolai Hopf, Hansjörg Bäzner, Hans Henkes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Single antiplatelet regimen in flow diverter treatment of cerebral aneurysms: The drug matters. A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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  3. Flow diverter retreatment for intracranial aneurysms: A meta-analysis of efficacy and feasibility.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Pooled it
  4. Flow Diversion in Ruptured Intracranial Aneurysms: A Meta-Analysis.AJNR. American journal of neuroradiology · 2017
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  16. Traumatic vertebral artery transection injury: illustrative case.Journal of neurosurgery. Case lessons · 2025
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  17. Hemodynamics in Cerebral Aneurysms and Parent Arteries With Incompletely Expanded Flow Diverter Stents.International journal for numerical methods in biomedical engineering · 2025
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  19. Flow diversion in the treatment of intracranial aneurysms using the novel FRED X device: An early experience from a single high-volume center.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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  20. Article

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sebastian FischerNeuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Stuttgart, Germany.
Zsolt Vajda
Marta Aguilar Perez
Elisabeth Schmid
Nikolai Hopf
Hansjörg Bäzner
Hans Henkes

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this study was to evaluate the safety and efficacy of the recently available flow diverter "pipeline embolization device" (PED) for the treatment of intracranial aneurysms and dissections.

methodsEighty-eight consecutive patients underwent an endovascular treatment of 101 intracranial aneurysms or dissections using the PED between September 2009 and January 2011. The targeted vessels include 79 (78%) in the anterior circulation and 22 (22%) in the posterior circulation. We treated 96 aneurysms and 5 vessel dissections. Multiple devices were implanted in 67 lesions (66%).

resultsOne technical failure of the procedure was encountered. Immediate exclusion of the target lesion was not observed. Angiographic follow-up examinations were carried out in 80 patients (91%) with 90 lesions and revealed complete cure of the target lesion(s) in 47 (52%), morphological improvement in 32 lesions (36%), and no improvement in 11 lesions (12%). Six major complications were encountered: one fatal aneurysm rupture, one acute and one delayed PED thrombosis, and three hemorrhages in the dependent brain parenchyma.

conclusionOur experience reveals that the PED procedure is technically straightforward for the treatment of selected wide-necked saccular aneurysms, fusiform aneurysms, remnants of aneurysms, aneurysms with a high likelihood of failure with conventional endovascular techniques, and dissected vessels. While vessel reconstruction, performed after dissection, is achieved within days, remodeling of aneurysmal dilatations may take several months. Dual platelet inhibition is obligatory. Parenchymal bleeding into brain areas dependent on the target vessel is uncommon.

Indexed as

Angiography, Digital SubtractionAortic DissectionCerebral AngiographyEmbolization, TherapeuticFemaleHumansIntracranial AneurysmMaleMiddle AgedRadiography, InterventionalTreatment Outcome

Identifiers

PMID21881914
PMCPMC3304061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.