ArticleInternational journal of colorectal disease2012
Despite aggressive histopathology survival is not impaired in young patients with colorectal cancer : CRC in patients under 50 years of age.
Article in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Time to diagnosis and treatment in younger adults with colorectal cancer: A systematic review.PloS one · 2022Pooled it
- Development and validation of a nomogram to predict overall survival in young non-metastatic rectal cancer patients after curative resection: a population-based analysis.International journal of colorectal disease · 2022Trial
- Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon.British journal of cancer · 2025Article
- Comparative analysis of sporadic, IBD-associated, early-onset and late-onset colorectal cancer: a systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2025Review
- A retrospective analysis of key predictors and patient outcomes: Using artificial intelligence for precision survival prediction in colorectal cancer.German medical science : GMS e-journal · 2025Article
- Age as a Predictor of Overall Survival in Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Nomogram model for predicting cancer-specific mortality in patients with early-onset colorectal cancer: a competing risk analysis insight from the SEER database and an external validation cohort.Translational cancer research · 2024Article
- Comparison of the short- and long-term prognosis of early-onset colorectal cancer compared with later-onset colorectal cancer: A systematic review and meta-analysis.Health science reports · 2023Article
- A Retrospective Multicenter Study of the Clinicopathological Characteristics and Prognosis of Young Adult Patients with Colorectal Cancer: Effects of Chemotherapy on Prognosis.Journal of clinical medicine · 2023Article
- Is early-onset cancer an emerging global epidemic? Current evidence and future implications.Nature reviews. Clinical oncology · 2022Review
- Young-Onset Colon Cancer: A Case Report.Cureus · 2022Article
- Clinicopathologic characteristics and prognosis of synchronous colorectal cancer: a retrospective study.BMC gastroenterology · 2022Article
- The short-term and oncologic outcomes of younger VS older colorectal cancer patients undergoing primary surgery: a propensity score matching analysis.BMC cancer · 2022Article
- Young-onset colorectal cancer: A review.World journal of gastrointestinal oncology · 2021Review
- Colorectal Cancer in Young and Older Adults in Uruguay: Changes in Recent Incidence and Mortality Trends.International journal of environmental research and public health · 2021Article
- Comparative genomic signatures in young and old Chinese patients with colorectal cancer.Cancer medicine · 2021Article
- Rising incidence of early-onset colorectal cancer - a call to action.Nature reviews. Clinical oncology · 2021Review
- Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review).International journal of molecular medicine · 2021Article
- Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study.World journal of gastrointestinal surgery · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeColorectal carcinoma (CRC) is generally a disease of persons older than 50 years. Concerning younger patients, controversies still exist regarding features and prognosis of CRC. We performed this study to characterize CRC in young patients (≤50 years) as well as to evaluate outcome in comparison with older patients (>50 years) with CRC.
methodsClinical and histopathological parameters of 244 patients aged 50 years or less were compared with 1,718 patients aged more than 50 years.
resultsCompared with older patients, the younger had less adenocarcinomas (82.8% vs. 89.1%; p = 0.004) and less postoperative complications (18.4% vs. 28.7%; p = 0.001), and less Union Internationale Contre le Cancer stage I colon cancers (22.9% vs. 13.6%, p = 0.046) but elevated overall 5-year survival rates for M0 colon and rectal cancers (p = 0.005; p < 0.001). In young patients, the minority suffered from hereditary cancer syndromes (7.4%) and inflammatory bowel diseases (7.0%). Furthermore, up to 40% of young patients denied any cancers in their families. Cancer-related survival rates were significantly elevated in young patients with M0 rectal carcinoma (p = 0.014), whereas in M0 colon cancers, no differences were detectable (p = 0.542). In case of the presence of distant metastases, overall and cancer-related survival rates were similar in old and young patients.
conclusionAlthough young patients present with more aggressive histopathological subtypes and less early stages, cancer-related survival is not less favourable compared with older patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.