ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2011
Morphine alters M. bovis infected microglia's ability to activate γδ T lymphocytes.
Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Active and latent tuberculosis among HIV-positive injecting drug users in Indonesia.Journal of the International AIDS Society · 2015Article
- Cellular prion protein participates in the regulation of inflammatory response and apoptosis in BV2 microglia during infection with Mycobacterium bovis.Journal of molecular neuroscience : MN · 2013Article
- Drugs of abuse effects on immunity and microbial pathogenesis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microglia, the macrophages of the central nervous system (CNS), are both the principle target cells for Mycobacterium infection in the CNS and serve a critical role in defense of the brain. If microglia's functions are altered due to immunosuppressive agents such as opiates, perturbation in defense of the brain may occur, including defense against CNS Tuberculosis. This study was designed to determine if Mycobacterium infected microglia activate γδT lymphocytes and if the opiate morphine alters the capability of microglia to activate γδT lymphocytes. γδT lymphocytes proliferated, produced IFN-γ, and demonstrated cytolytic response upon exposure to Mycobacterium bovis infected microglia. IFN-γ, and antigen specific cytotoxicity were both markedly impaired due to morphine treatment.
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