ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
Homozygosity for the +674C>T polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 5 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 5 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Association between VEGF-A and VEGFR-2 polymorphisms and response to treatment of neovascular AMD with anti-VEGF agents: a meta-analysis.The British journal of ophthalmology · 2017Pooled it
- Association between Vascular Endothelial Growth Factor Polymorphisms and Age-Related Macular Degeneration: An Updated Meta-Analysis.Disease markers · 2016Pooled it
- Roles of three common VEGF polymorphisms in the risk of age-related macular degeneration.Genetic testing and molecular biomarkers · 2014Pooled it
- Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis.Molecular vision · 2013Pooled it
- Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration.Molecular biology reports · 2012Pooled it
- VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: comparison of age-related macular degeneration treatments trials (CATT).JAMA ophthalmology · 2014Trial
- Using current data to define new approach in age related macular degeneration: need to accelerate translational research.Current genomics · 2014Article
- Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population.International journal of ophthalmology · 2014Article
- AMD-associated genes encoding stress-activated MAPK pathway constituents are identified by interval-based enrichment analysis.PloS one · 2013Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association between VEGF gene polymorphism and age-related macular degeneration (AMD) in a Brazilian cohort.
methodsWe examined 160 affected individuals and 140 sex- and age-matched controls recruited at the Vision Institute and the Retina Department, São Geraldo Hospital, Minas Gerais Federal University, Brazil, between 2007 and 2011. Genotyping for the VEGF rs1413711 single nucleotide polymorphism (SNP) (+674C>T) was performed. The incidence rate ratios and 95% confidence interval (CI) for AMD for this genotype was calculated. The odds ratio (OR) was also assessed by using logistic regression, controlling for CFH and LOC387715 risk genotype.
resultsWe observed a prevalence of homozygosity (TT genotype) of 18.1% for rs1413711 among AMD cases compared with 5.8% among controls (P < 0.002). The ORs for this polymorphism were 3.6 (95%CI 1.6-8.2) for homozygous subjects and 1.5 (95%CI 1.1-2.1, P < 0.01) if the subject had at least one risk allele. When we studied separately exudative and dry AMD groups, this polymorphism was statistically significant for both groups. Controlling for CFH and LOC387715 risk genotype the OR was 3.0 for VEGF homozygous, and the OR increases if the patient is homozygous for the three genes.
conclusionThe present data suggests that VEGF TT genotype is associated with AMD among Brazilian patients.
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