ArticleThe Journal of infectious diseases2011
Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Prevalence and Risk of Meningococcal Disease or Carriage During Mass Gatherings and Associated Travel: Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2025Review
- Geographical and temporal variations of serogroups and clonal types ofJournal of medical microbiology · 2025Article
- Modelling evolutionary pathways for commensalism and hypervirulence inMicrobial genomics · 2021Article
- Meningococcal carriage in periods of high and low invasive meningococcal disease incidence in the UK: comparison of UKMenCar1-4 cross-sectional survey results.The Lancet. Infectious diseases · 2021Article
- Deconvolution of intergenic polymorphisms determining high expression of Factor H binding protein in meningococcus and their association with invasive disease.PLoS pathogens · 2021Article
- Article
- Suspected cluster ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence.Wellcome open research · 2019Article
- Impact of meningococcal C conjugate vaccination programs with and without catch-up campaigns in adolescents: Lessons learned from Bahia, Brazil.Human vaccines & immunotherapeutics · 2018Article
- The Impact of Nucleotide Sequence Analysis on Meningococcal Vaccine Development and Assessment.Frontiers in immunology · 2018Review
- Genomic analysis of urogenital and rectalSexually transmitted infections · 2017Article
- Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa.BMC microbiology · 2017Article
- Population and Functional Genomics of Neisseria Revealed with Gene-by-Gene Approaches.Journal of clinical microbiology · 2016Review
- Review
- Impact of vaccination on meningococcal epidemiology.Human vaccines & immunotherapeutics · 2016Review
- Serogroup and Clonal Characterization of Czech Invasive Neisseria meningitidis Strains Isolated from 1971 to 2015.PloS one · 2016Article
- The Diversity of Meningococcal Carriage Across the African Meningitis Belt and the Impact of Vaccination With a Group A Meningococcal Conjugate Vaccine.The Journal of infectious diseases · 2015Article
- Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Clonal analysis of meningococci during a 26 year period prior to the introduction of meningococcal serogroup C vaccines.PloS one · 2015Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
backgroundHerd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population.
methodsCarried meningococci in individuals aged 15-19 years attending education establishments were investigated before and for 2 years after vaccine introduction. Isolates were characterized by multilocus sequence typing, serogroup, and capsular region genotype and changes in phenotypes and genotypes assessed.
resultsA total of 8462 meningococci were isolated from 47 765 participants (17.7%). Serogroup prevalence was similar over the 3 years, except for decreases of 80% for serogroup C and 40% for serogroup 29E. Clonal complexes were associated with particular serogroups and their relative proportions fluctuated, with 12 statistically significant changes (6 up, 6 down). The reduction of ST-11 complex serogroup C meningococci was probably due to vaccine introduction. Reasons for a decrease in serogroup 29E ST-254 meningococci (from 1.8% to 0.7%) and an increase in serogroup B ST-213 complex meningococci (from 6.7% to 10.6%) were less clear.
conclusionsNatural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine introduction.
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