ArticleJournal of clinical microbiology2011
First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Fatal disseminatedJournal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Article
- Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Article
- Disseminated Mycobacterium haemophilum infection in a renal transplant recipient.BMJ case reports · 2016Article
- Non-tuberculous mycobacterial infections in solid organ transplant recipients: An update.Journal of clinical tuberculosis and other mycobacterial diseases · 2016Review
- A Challenging Case of Multifocal Mycobacterium marinum Osteoarticular Infection in a Patient with Anorexia Nervosa.Case reports in orthopedics · 2015Article
- Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers.Emerging microbes & infections · 2015Article
- Report of disseminated Mycobacterium haemophilum infection after double cord blood allo-SCT.Bone marrow transplantation · 2014Article
- Update on nontuberculous mycobacterial infections in solid organ and hematopoietic stem cell transplant recipients.Current infectious disease reports · 2014Article
- Infections caused by non-tuberculous mycobacteria in recipients of hematopoietic stem cell transplantation.Frontiers in oncology · 2014Review
- Romance of the three domains: how cladistics transformed the classification of cellular organisms.Protein & cell · 2013Review
- [The fate of 20 sea breams. Mycobacterium marinum infection].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2012Article
- Automated pangenomic analysis in target selection for PCR detection and identification of bacteria by use of ssGeneFinder Webserver and its application to Salmonella enterica serovar Typhi.Journal of clinical microbiology · 2012Article
- Detection of microorganisms in granulomas that have been formalin-fixed: review of the literature regarding use of molecular methods.Scientifica · 2012Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present here the first report of disseminated skin Mycobacterium infections in two liver transplant recipients, in which hsp65 gene sequencing was used for rapid species identification. Both patients had hepatitis B virus-related cirrhosis and diabetes mellitus and presented with progressive generalized, nodular skin lesions. In one patient, a 50-year-old woman who had frequent contact with marine fish, an acid-fast bacillus was isolated from skin biopsy tissue after 2 months of culture. While awaiting phenotypic identification results, hsp65 gene sequencing showed that it was most closely related to that of Mycobacterium marinum with 100% nucleotide identity. The patient was treated with oral rifampin, ethambutol, and moxifloxacin. In the other patient, a 59-year-old woman, direct PCR for Mycobacterium using hsp65 gene from skin biopsy tissue was positive, with the sequence most closely related to that of M. haemophilum with 100% nucleotide identity. Based on PCR results, the patient was treated with clarithromycin, ethambutol, moxifloxacin, and amikacin. A strain of M. haemophilum was only isolated after 3 months. Skin lesions of both patients resolved after 1 year of antimycobacterial therapy. Nontuberculous Mycobacterium infections should be considered in liver transplant recipients presenting with chronic, nodular skin lesions. This report highlights the crucial role of hsp65 gene PCR and sequencing on both cultured isolates and direct clinical specimens for rapid diagnosis of slow-growing Mycobacterium infection.
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