ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Involvement of newborn neurons in olfactory associative learning? The operant or non-operant component of the task makes all the difference.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms.Communications biology · 2024Article
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice.Frontiers in neuroscience · 2023Article
- Neural processing of the reward value of pleasant odorants.Current biology : CB · 2021Article
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction.PLoS computational biology · 2019Article
- Kinase activity in the olfactory bulb is required for odor memory consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Article
- The Physiological Foresight in Freeman's Work: Predictions and Verifications.Journal of consciousness studies : controversies in science & the humanities · 2018Article
- Article
- Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Topographical representation of odor hedonics in the olfactory bulb.Nature neuroscience · 2016Article
- The Role of Adult-Born Neurons in the Constantly Changing Olfactory Bulb Network.Neural plasticity · 2016Review
- Adult stem cells in neural repair: Current options, limitations and perspectives.World journal of stem cells · 2015Review
- Adult neurogenesis is necessary to refine and maintain circuit specificity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Aging in the olfactory system.Trends in neurosciences · 2014Review
- A lifetime of neurogenesis in the olfactory system.Frontiers in neuroscience · 2014Review
- How neurogenesis finds its place in a hardwired sensory system.Frontiers in neuroscience · 2014Review
- Age-dependent regional changes in the rostral migratory stream.Neurobiology of aging · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New neurons are continuously generated in the adult mammalian olfactory bulb. The role of these newborn neurons in olfactory learning has been debated. Blocking the addition of neurons has been reported either to result in memory alteration or to have no effect at all (Imayoshi et al., 2008; Breton-Provencher et al., 2009; Lazarini et al., 2009; Sultan et al., 2010). These discrepancies may have arisen from differences in the behavioral paradigms used: operant procedures indicated that neurogenesis blockade had substantial effects on long-term memory (Lazarini et al., 2009; Sultan et al., 2010) whereas other methods had little effect (Imayoshi et al., 2008; Breton-Provencher et al., 2009). Surprisingly, while operant learning is known to modulate the survival of new neurons, the effect of non-operant learning on newborn cells is unknown. Here we use mice to show that compared with operant learning, non-operant learning does not affect cell survival, perhaps explaining the current controversy. In addition, we provide evidence that distinct neural substrates at least partly underlie these two forms of learning. We conclude that the involvement of newborn neurons in learning is subtly dependent on the nature of the behavioral task.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.