ArticleClinical and vaccine immunology : CVI2011
Dexamethasone-induced cytokine changes associated with diminished disease severity in horses infected with Anaplasma phagocytophilum.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Cytokine pattern during asymptomatic Anaplasma spp. infections and effect of co-infections by malaria and helminths in schoolchildren of Franceville, southeastern Gabon.Parasites & vectors · 2025Article
- Temporal patterns of gene expression in response to inoculation with a virulent Anaplasma phagocytophilum strain in sheep.Scientific reports · 2023Article
- Development of a Syndromic Molecular Diagnostic Assay for Tick-Borne Pathogens Using Barcoded Magnetic Bead Technology.Microbiology spectrum · 2023Article
- Innate immunity in rickettsial infections.Frontiers in cellular and infection microbiology · 2023Review
- A road map for in vivo evolution experiments with blood-borne parasitic microbes.Molecular ecology resources · 2022Review
- VirB10 vaccination for protection against Anaplasma phagocytophilum.BMC microbiology · 2018Article
- Article
- Influence of Genetic Background on Hematologic and Histopathologic Alterations during Acute Granulocytic Anaplasmosis in 129/SvEv and C57BL/6J Mice Lacking Type I and Type II Interferon Signaling.Comparative medicine · 2017Article
- Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis.PloS one · 2017Article
- The role of CD8 T lymphocytes in rickettsial infections.Seminars in immunopathology · 2015Review
- Stat1 negatively regulates immune-mediated injury with Anaplasma phagocytophilum infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Comparison and characterization of granulocyte cell models for Anaplasma phagocytophilum infection.Pathogens and disease · 2014Article
- Anaplasma phagocytophilum, interferon gamma production and Stat1 signaling.Microbiology and immunology · 2013Article
- The biological basis of severe outcomes in Anaplasma phagocytophilum infection.FEMS immunology and medical microbiology · 2012Review
- Common and atypical presentations of Anaplasma phagocytophilum infection in equids with emphasis on neurologic and muscle disease.Journal of veterinary internal medicineArticle
- Cavitary effusion associated with Anaplasma phagocytophilum infection in 2 equids.Journal of veterinary internal medicineArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Anaplasma phagocytophilum is the zoonotic cause of granulocytic anaplasmosis. We hypothesized that immune response, specifically gamma interferon (IFN-γ), plays a role in disease severity. To test this, horses were infected and IFNG expression was pharmacologically downregulated using corticosteroids. Eight horses were infected with A. phagocytophilum; 4 received dexamethasone on days 4 to 8 of infection. Clinical signs, hematologic parameters, and transcription of cytokine/chemokine genes were compared among treated and untreated horses. Infection was quantitated by msp2 real-time PCR and microscopy. As anticipated, there was significantly greater leukopenia, thrombocytopenia, and anemia in infected versus uninfected horses. The A. phagocytophilum load was higher for dexamethasone-treated horses. Dexamethasone reduced IFNG transcription by day 12 and IL-8 and IL-18 by days 7 to 9 and increased IL-4 on day 7. The ratio of IL-10 to IFNG was increased by dexamethasone on day 9. There were no hematologic differences between the infected horses. Dexamethasone suppression of proinflammatory response resulted in delayed infection-induced limb edema and decreased icterus, anorexia, and reluctance to move between days 6 and 9 and lower fever on day 7. These results underscore the utility of the equine model of granulocytic anaplasmosis and suggest that Th1 proinflammatory response plays a role in worsening disease severity and that disease severity can be decreased by modulating proinflammatory response. A role for Th1 response and macrophage activation in hematologic derangements elicited by A. phagocytophilum is not supported by these data and remains unproven.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.