ArticleRNA (New York, N.Y.)2011
The presence of multiple introns is essential for ERECTA expression in Arabidopsis.
Article in RNA (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Impact of U2-type introns on splice site prediction in A. thaliana species using deep learning.BMC bioinformatics · 2025Article
- A novel MoClo-mediated intron insertion system facilitates enhanced transgene expression inFrontiers in plant science · 2025Article
- An LTR retrotransposon insertion inside CsERECTA for an LRR receptor-like serine/threonine-protein kinase results in compact (cp) plant architecture in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response.The Plant cell · 2022Article
- Enhanced biomass and thermotolerance ofPeerJ · 2022Article
- Genome-Wide Identification of LRR-RLK Family inCurrent issues in molecular biology · 2021Article
- The working dead: repurposing inactive CRISPR-associated nucleases as programmable transcriptional regulators in plants.aBIOTECH · 2020Review
- Identification and expression analysis of ERECTA family genes in grape (Vitis vinifera L.).Genes & genomics · 2019Article
- EPFL Signals in the Boundary Region of the SAM Restrict Its Size and Promote Leaf Initiation.Plant physiology · 2019Article
- Identification and Characterization ofCells · 2018Article
- Phylogenetic and CRISPR/Cas9 Studies in Deciphering the Evolutionary Trajectory and Phenotypic Impacts of RiceFrontiers in plant science · 2018Article
- Identification of critical functional residues of receptor-like kinase ERECTA.Journal of experimental botany · 2017Article
- Origin and diversification of leucine-rich repeat receptor-like protein kinase (LRR-RLK) genes in plants.BMC evolutionary biology · 2017Article
- Demethylation of ERECTA receptor genes by IBM1 histone demethylase affects stomatal development.Development (Cambridge, England) · 2016Article
- Duplication and Divergence of Leucine-Rich Repeat Receptor-Like Protein Kinase (Frontiers in plant science · 2016Article
- ERECTA and BAK1 Receptor Like Kinases Interact to Regulate Immune Responses in Arabidopsis.Frontiers in plant science · 2016Article
- Rice Ribosomal Protein Large Subunit Genes and Their Spatio-temporal and Stress Regulation.Frontiers in plant science · 2016Article
- Genomic Dissection and Expression Profiling Revealed Functional Divergence inFrontiers in plant science · 2016Article
- Genomic and Post-Translational Modification Analysis of Leucine-Rich-Repeat Receptor-Like Kinases in Brassica rapa.PloS one · 2015Article
- Co-Immunoprecipitation of Membrane-Bound Receptors.The arabidopsis book · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression in eukaryotes is often enhanced by the presence of introns. Depending on the specific gene, this enhancement can be minor or very large and occurs at both the transcriptional and post-transcriptional levels. The Arabidopsis ERECTA gene contains 27 exons encoding a receptor-like kinase that promotes cell proliferation and inhibits cell differentiation in above-ground plant organs. The expression of ERECTA very strongly depends on the presence of introns. The intronless ERECTA gene does not rescue the phenotype of erecta mutant plants and produces about 500-900 times less protein compared with the identical construct containing introns. This result is somewhat surprising as the region upstream of the ERECTA coding sequence effectively promotes the expression of extraneous genes. Here, we demonstrate that introns are essential for ERECTA mRNA accumulation and, to a lesser extent, for mRNA utilization in translation. Since mRNA produced by intronless ERECTA is degraded at the 3' end, we speculate that introns increase mRNA accumulation through increasing its stability at least in part. No individual intron is absolutely necessary for ERECTA expression, but rather multiple introns in specific locations increase ERECTA expression in an additive manner. The ability of introns to promote ERECTA expression might be linked to the process of splicing and not to a particular intron sequence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.