Evidence map›Paper›PMID 21880761›Full record

ArticleJournal of virology2011

Characterization of a canine homolog of human Aichivirus.

Amit Kapoor, Peter Simmonds, Edward J Dubovi, Natasha Qaisar, Jose A Henriquez, Jan Medina, Shelly Shields, W Ian Lipkin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 92 citations in OpenAlex.

  1. Prevalence and Genomic Features of Aichivirus D in Yaks in Western China.Animals : an open access journal from MDPI · 2026
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  6. Article
  7. Identification of Recombinant Aichivirus D in Cattle, Italy.Animals : an open access journal from MDPI · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Molecular characterization of canine and feline kobuvirus infections in Iran.Veterinary research forum : an international quarterly journal · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Amit KapoorCenter for Infection and Immunity, Columbia University, 722 West 168th Street, New York, NY 10032, USA. ak3117@columbia.edu
Peter Simmonds
Edward J Dubovi
Natasha Qaisar
Jose A Henriquez
Jan Medina
Shelly Shields
W Ian Lipkin
Columbia University · USCornell University · USPfizer (United States) · USUniversity of Edinburgh · GB

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LIPKIN, W. IAN · 2003 to 2014
$100.8M
Development of Complement Modulating Therapeutics for AMDR24EY017404 · NEI · UNIVERSITY OF UTAH · PI HAGEMAN, GREGORY S · 2006 to 2010
$14.8M
Identification and characterization of cellular factors involved in HCV entryR01AI072613 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2007 to 2016
$4.7M
Viral Arrays for BiodefenseU01AI070411 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2006 to 2010
$4.4M
Risk of Viral Emergence from BatsR01AI079231 · NIAID · ECOHEALTH ALLIANCE, INC. · PI DASZAK, PETER · 2008 to 2012
$2.6M
Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virusR01AI090055 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2010 to 2014
$2.1M
Molecular Characterization of Novel AstrovirusesR21AI090196 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KAPOOR, AMIT · 2010 to 2011
$454k
Study of a novel picornavirus genus associated with Acute Flaccid ParalysisR21AI081132 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KAPOOR, AMIT · 2011 to 2012
$448k
NEI NIH HHS EY017404NEI NIH HHS R24 EY017404NIAID NIH HHS AI070411NIAID NIH HHS AI072613NIAID NIH HHS AI079231NIAID NIH HHS AI081132NIAID NIH HHS AI090055NIAID NIH HHS AI090196NIAID NIH HHS AI57158NIAID NIH HHS R01 AI072613NIAID NIH HHS R01 AI079231NIAID NIH HHS R01 AI090055NIAID NIH HHS R21 AI081132NIAID NIH HHS R21 AI090196NIAID NIH HHS U01 AI070411NIAID NIH HHS U54 AI057158Wellcome Trust 095831
6 · The paper itself

Abstract

Many of our fatal "civilization" infectious diseases have arisen from domesticated animals. Although picornaviruses infect most mammals, infection of a companion animal is not known. Here we describe the identification and genomic characterization of the first canine picornavirus. Canine kobuvirus (CKoV), identified in stool samples from dogs with diarrhea, has a genomic organization typical of a picornavirus and encodes a 2,469-amino-acid polyprotein flanked by 5' and 3' untranslated regions. Comparative phylogenetic analysis using various structural and nonstructural proteins of CKoV confirmed it as the animal virus homolog most closely related to human Aichivirus (AiV). Bayesian Markov chain Monte Carlo analysis suggests a mean recent divergence time of CKoV and AiV within the past 20 to 50 years, well after the domestication of canines. The discovery of CKoV provides new insights into the origin and evolution of AiV and the species specificity and pathogenesis of kobuviruses.

Indexed as

Genome, Viral3' Untranslated Regions5' Untranslated RegionsAnimalsCluster AnalysisDiarrheaDog DiseasesDogsFecesKobuvirusMolecular Sequence DataPhylogenyPicornaviridae InfectionsRNA, ViralSequence Analysis, DNASequence Homology3' Untranslated Regions5' Untranslated RegionsRNA, Viral

Identifiers

PMID21880761
PMCPMC3194941
OpenAlexW2137214652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.