ArticleJournal of virology2011
Infection of calves with bovine norovirus GIII.1 strain Jena virus: an experimental model to study the pathogenesis of norovirus infection.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
- Clinical and Epidemiological Features of Calicivirus Infections in Cattle.Animals : an open access journal from MDPI · 2026Review
- Immunogenicity of a bivalent recombinant adenovirus expressing VP1 proteins of bovine norovirus and bovine nebovirus in mice and calves.BMC microbiology · 2025Article
- Molecular characteristics of bovine norovirus and nebovirus in Swedish dairy herds.Acta veterinaria Scandinavica · 2025Article
- Prevalence and genetic characterization of diarrhea viruses among cattle in Guangdong, China.BMC veterinary research · 2025Article
- Immunogenicity of Virus-like Particles Based on VP1 Protein of Bovine Norovirus.Veterinary sciences · 2025Article
- Molecular characterization of ten viral pathogens causing calf diarrhea in Hanwoo (Bos Taurus coreanae) by next generation sequencing.BMC veterinary research · 2025Article
- In Vitro Culture of Human Norovirus in the Last 20 Years.Biomedicines · 2024Review
- A highly divergent enteric calicivirus in a bovine calf in India.Archives of virology · 2024Article
- Epidemiological investigation of norovirus infections in Punjab, Pakistan, through the One Health approach.Frontiers in public health · 2023Article
- A multiplex real-time fluorescence-based quantitative PCR assay for calf diarrhea viruses.Frontiers in microbiology · 2023Article
- Immunodominant B-Cell Linear Epitope on the VP1 P Domain of a Feline Norovirus Cat Model.Pathogens (Basel, Switzerland) · 2022Article
- Literature Review: Coinfection in Young Ruminant Livestock-Pathogens (Basel, Switzerland) · 2022Review
- Article
- Prevalence and complete genome of bovine norovirus with novel VP1 genotype in calves in China.Scientific reports · 2019Article
- Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges.Viruses · 2019Review
- In Vitro Replication of Human Norovirus.Viruses · 2019Review
- Animals as Reservoir for Human Norovirus.Viruses · 2019Review
- Molecular characterization of bovine noroviruses and neboviruses in Turkey: detection of recombinant strains.Archives of virology · 2019Article
- The Dual Tropism of Noroviruses.Journal of virology · 2018Review
- Phylogeny of bovine norovirus in Egypt based on VP2 gene.International journal of veterinary science and medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The experimental infection of newborn calves with bovine norovirus was used as a homologous large animal model to study the pathogenesis of norovirus infection and to determine target cells for viral replication. Six newborn calves were inoculated orally with Jena virus (JV), a bovine norovirus GIII.1 strain, and six calves served as mock-inoculated controls. Following infection, calves were euthanized before the onset of diarrhea (12 h postinoculation [hpi]), shortly after the onset of diarrhea (18 to 21 hpi), and postconvalescence (4 days pi [dpi]). Calves inoculated with JV developed severe watery diarrhea at 14 to 16 hpi, and this symptom lasted for 53.5 to 67.0 h. Intestinal lesions were characterized by severe villus atrophy together with loss and attenuation of villus epithelium. Viral capsid antigen (JV antigen) was detected by immunohistochemistry in the cytoplasm of epithelial cells on villi. In addition, granular material positive for JV antigen was detected in the lamina propria of villi. Lesions first appeared at 12 hpi and were most extensive at 18 to 19 hpi, extending from midjejunum to ileum. The intestinal mucosa had completely recovered at 4 dpi. There was no indication of systemic infection as described for norovirus infection in mice. JV was found in intestinal contents by reverse transcription-PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) as early as 12 hpi. Fecal shedding of the virus started at 13 hpi and stopped at 23 hpi or at necropsy (4 dpi), respectively. Throughout the trial, none of the control calves tested positive for JV by ELISA or RT-PCR.
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Registered trials
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