ArticleThe Journal of biological chemistry2011
The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 126 citations in OpenAlex.
- U2AF1 modulates alternative exon selection and guards zygotic splicing activation in mouse preimplantation embryogenesis.Cellular and molecular life sciences : CMLS · 2026Article
- Chaperonin in health and disease.Molecular biomedicine · 2026Review
- Morphological and proteomic characterization of sperm in a beluga whale (Delphinapterus leucas):a case report.Veterinary research communications · 2026Article
- Functional Methods for Studying Sperm-Zona Pellucida Interaction in Mammals.Methods and protocols · 2025Review
- Article
- Proteomic Analysis of Domestic Cat Blastocysts and Their Secretome Produced in an In Vitro Culture System without the Presence of the Zona Pellucida.International journal of molecular sciences · 2024Article
- Article
- The Ubiquitin-Proteasome System Participates in Sperm Surface Subproteome Remodeling during Boar Sperm Capacitation.Biomolecules · 2023Article
- Molecular insights on skewing of sex ratio in rabbits (Veterinary research forum : an international quarterly journal · 2023Article
- Article
- The life history ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular Interactions Associated with Oxidative Stress-Mediated Male Infertility: Sperm and Seminal Plasma Proteomics.Advances in experimental medicine and biology · 2022Review
- Upregulation of CCT3 promotes cervical cancer progression through FN1.Molecular medicine reports · 2021Article
- Influence of Extracellular Vesicles of the Follicular Fluid on Morphofunctional Characteristics of Human Sperm.Bulletin of experimental biology and medicine · 2021Article
- Nitric oxide-targeted protein phosphorylation during human sperm capacitation.Scientific reports · 2021Article
- Population structure of chum salmon and selection on the markers collected for stock identification.Ecology and evolution · 2021Article
- MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.Life science alliance · 2021Article
- Review
- Article
- Proteomic Profiling of Seminal Plasma Proteins in Varicocele Patients.The world journal of men's health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm-oocyte interactions are among the most remarkable processes in cell biology. These cellular recognition events are initiated by an exquisitely specific adhesion of free-swimming spermatozoa to the zona pellucida, an acellular matrix that surrounds the ovulated oocyte. Decades of research focusing on this interaction have led to the establishment of a widely held paradigm that the zona pellucida receptor is a single molecular entity that is constitutively expressed on the sperm cell surface. In contrast, we have employed the techniques of blue native-polyacrylamide gel electrophoresis, far Western blotting, and proximity ligation to secure the first direct evidence in support of a novel hypothesis that zona binding is mediated by multimeric sperm receptor complex(es). Furthermore, we show that one such multimeric association, comprising the chaperonin-containing TCP1 complex (CCT/TRiC) and a zona-binding protein, zona pellucida-binding protein 2, is present on the surface of capacitated spermatozoa and could account for the zona binding activity of these cells. Collectively, these data provide an important biochemical insight into the molecular basis of sperm-zona pellucida interaction and a plausible explanation for how spermatozoa gain their ability to fertilize.
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