ReviewAnnals of botany2011
Flavonols: old compounds for old roles.
Review in Annals of botany, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
128 citing papers in PubMed, 389 citations in OpenAlex.
- CsWRKY22 positively regulates quercetin biosynthesis by activating the CsFLSd promoter in tea plants (Camellia sinensis).Plant cell reports · 2026Article
- Early-stage diagnosis of nutrient deficiency by chlorophyll fluorescence in maize.Plant biology (Stuttgart, Germany) · 2026Article
- From structural features to mouse acute intraperitoneal toxicity prediction: a triple computational toxicology approach for safety assessment of flavonoids.Molecular diversity · 2026Article
- Untargeted metabolomics suggests a trade-off between phenolamides and flavonoids in the pollen of Petunia hybrida with contrasting flower colours.BMC plant biology · 2026Article
- LlR3MYB-mediated flavonoid biosynthesis confers cold stress tolerance inHorticulture research · 2026Article
- Boundary-line trade-off in bryophytes between UV photoprotection and photosynthetic capacity, but not desiccation tolerance.Annals of botany · 2026Article
- Environmental control of anthraquinone-flavonoid accumulation in wild plant species: biosynthetic pathways, ecological drivers, and adaptive significance.Frontiers in plant science · 2026Review
- A time-resolved metabolomics study of potato cultivar responses toFrontiers in plant science · 2026Article
- While end-of-production sole-source lighting at a moderate intensity increased nutrient, water-soluble vitamin, and carotenoid content, the anthocyanin concentration of red leaf lettuce decreased.Frontiers in plant science · 2026Article
- CoExpPhylo - a novel pipeline for biosynthesis gene discovery.BMC genomics · 2025Article
- The genetic basis of replicated bullseye pattern reduction across the Hibiscus trionum complex.The New phytologist · 2025Article
- Effect of Low Temperature and Nitrogen Modified Atmosphere Treatments on the Storage of High Moisture Indica Rice: Quality, Microstructure, and Metabolome Characteristics.Foods (Basel, Switzerland) · 2025Article
- Molecular underpinnings ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Blue and red LEDs modulate polyphenol production in Precoce and Tardiva cultivars ofFrontiers in plant science · 2025Article
- Antioxidants by nature: an ancient feature at the heart of flavonoids' multifunctionality.The New phytologist · 2025Article
- Comparative investigation of metabolite signatures and hypoadiposity effect between Dali tea and Yunkang tea.Food chemistry: X · 2024Article
- Evaluating the Effects of Flavonoids on Insects: Implications for Managing Pests Without Harming Beneficials.Insects · 2024Review
- The evolution of flavonoid biosynthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A decade of rain exclusion in a Mediterranean forest reveals trade-offs of leaf chemical defenses and drought legacy effects.Scientific reports · 2024Article
- Effects of High Salinity and Water Stress on Wetland Grasses from the Spanish Mediterranean Coast.Plants (Basel, Switzerland) · 2024Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew roles for flavonoids, as developmental regulators and/or signalling molecules, have recently been proposed in eukaryotic cells exposed to a wide range of environmental stimuli. In plants, these functions are actually restricted to flavonols, the ancient and widespread class of flavonoids. In mosses and liverworts, the whole set of genes for flavonol biosynthesis - CHS, CHI, F3H, FLS and F3'H - has been detected. The flavonol branch pathway has remained intact for millions of years, and is almost exclusively involved in the responses of plants to a wide array of stressful agents, despite the fact that evolution of flavonoid metabolism has produced >10 000 structures. SCOPE: Here the emerging functional roles of flavonoids in the responses of present-day plants to different stresses are discussed based on early, authoritative views of their primary functions during the colonization of land by plants. Flavonols are not as efficient as other secondary metabolites in absorbing wavelengths in the 290-320 nm spectral region, but display the greatest potential to keep stress-induced changes in cellular reactive oxygen species homeostasis under control, and to regulate the development of individual organs and the whole plant. Very low flavonol concentrations, as probably occurred in early terrestrial plants, may fully accomplish these regulatory functions.
conclusionsDuring the last two decades the routine use of genomic, chromatography/mass spectrometry and fluorescence microimaging techniques has provided new insights into the regulation of flavonol metabolism as well as on the inter- and intracellular distribution of stress-responsive flavonols. These findings offer new evidence on how flavonols may have performed a wide array of functional roles during the colonization of land by plants. In our opinion this ancient flavonoid class is still playing the same old and robust roles in present-day plants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.