Trial reportHaematologica2011
Newly diagnosed immune thrombocytopenia in children and adults: a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group.
Trial report in Haematologica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Thromboembolism in patients with immune thrombocytopenia (ITP): a meta-analysis of observational studies.International journal of hematology · 2016Pooled it
- Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review.Journal of thrombosis and haemostasis : JTH · 2015Pooled it
- IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP.Blood advances · 2020Trial
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Effect of Romiplostim on Health-Related Quality of Life in Children with Primary Immune Thrombocytopenia and Associated Burden in Their Parents.Pediatric blood & cancer · 2016Trial
- Where would immune thrombocytopenia be without intravenous gammaglobulin?Haematologica · 2026Article
- Spontaneous spinal epidural hematoma in the setting of Evans syndrome: a case report and literature review.Journal of spine surgery (Hong Kong) · 2026Article
- Multicenter initiative to standardize management of pediatric immune thrombocytopenia improves adherence to guidelines.Blood advances · 2026Article
- Adherence to ITP guidelines and adequate immunotherapy.Blood advances · 2026Article
- Enhancing Immune Thrombocytopenia Education and Support: Insights From a Learning Exchange Program.Journal of the advanced practitioner in oncology · 2026Article
- Clinical Characteristics and Predictors of Chronicity in Children With Immune Thrombocytopenia.Cureus · 2026Article
- Life-threatening intraparenchymal hematoma due to immune thrombocytopenic purpura: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Prognostic Re-evaluation of Antinuclear Antibodies in Childhood Immune Thrombocytopenia.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Paediatric Hospitalised Immune Thrombocytopenia in Real-Life Recent Viral Infection Outbreaks: A Retrospective Study.Life (Basel, Switzerland) · 2025Article
- Efficacy of Short-Course High-Dose Oral Prednisolone in Rapid Platelet Recovery for Pediatric Acute Immune Thrombocytopenic Purpura: A Prospective Cohort Study.Journal of hematology · 2025Article
- Prediction of moderate to severe bleeding risk in pediatric immune thrombocytopenia using machine learning.European journal of pediatrics · 2025Article
- Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia.Blood advances · 2024Article
- Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.Nature communications · 2024Article
- Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis.Vaccines · 2024Review
- Epidemiology of immune thrombocytopenia: study of adult patients at a referral hematology service in Northeastern Brazil.Hematology, transfusion and cell therapy · 2024Article
- Tapering and Sustained Remission of Thrombopoietin Receptor Agonists (TPO-RAs): Is it Time for Paediatric ITP?Advances in therapy · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary immune thrombocytopenia is a bleeding diathesis with an unknown etiology in predisposed individuals with immune disturbances. Although it is claimed that children and adults differ in clinical and laboratory aspects, few data exist to corroborate this observation. Our objective was to assess comparative data from children and adults with newly diagnosed immune thrombocytopenia. DESIGN AND
methodsClinical and laboratory data of 1,784 children and 340 adults were extracted from the Pediatric and Adult Registry on Chronic Immune Thrombocytopenia. The registry represents a prospective cohort of children and adults with newly diagnosed immune thrombocytopenia. Participating investigators registered their patients immediately after the diagnosis using a web based data transfer. Children aged under 16 years were compared with adults aged 16 years and over with descriptive statistical analyses.
resultsThe presenting mean platelet count of children and adults was 18.1 and 25.4 × 10(9)/L. Signs of bleeding were reported in 24% of children and in 23% of adults, and intracranial hemorrhage in 10 of 1,784 children and in 6 of 340 adults. Co-morbidity was observed in 3.9% of children and in 30% of adults. Bone marrow aspiration and laboratory tests (antinuclear antibodies, human immunodeficiency and hepatitis C virus) were performed more frequently in adults. Children and adults were followed with a 'watch and wait' strategy in 20% and in 29%, respectively. Immunoglobulins were used more frequently in children and corticosteroids in adults.
conclusionsComparative data of children and adults with newly diagnosed immune thrombocytopenia revealed similarities in presenting platelet counts and in bleeding, whereas differences occurred in co-morbidity, diagnostic procedures and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.