ArticleJournal of the Royal Society, Interface2012
Stochastic properties of the plant circadian clock.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Self-organization underlies developmental robustness in plants.Cells & development · 2025Review
- Review
- Abundant clock proteins point to missing molecular regulation in the plant circadian clock.Molecular systems biology · 2025Article
- Dissecting the complexity of local and systemic circadian communication in plants.Npj biological timing and sleep · 2024Review
- Red Light Resets the Expression Pattern, Phase, and Period of the Circadian Clock in Plants: A Computational Approach.Biology · 2022Article
- Review
- What is quantitative plant biology?Quantitative plant biology · 2021Review
- Signaling pathways have an inherent need for noise to acquire information.BMC bioinformatics · 2020Article
- Circadian gating of dark-induced increases in chloroplast- and cytosolic-free calcium in Arabidopsis.The New phytologist · 2020Article
- Arabidopsis JMJD5/JMJ30 Acts Independently of LUX ARRHYTHMO Within the Plant Circadian Clock to Enable Temperature Compensation.Frontiers in plant science · 2019Article
- Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.PLoS computational biology · 2019Article
- Article
- Circadian Rhythms and Redox State in Plants: Till Stress Do Us Part.Frontiers in plant science · 2018Article
- Targeting Bayes factors with direct-path non-equilibrium thermodynamic integration.Computational statistics · 2017Article
- Approximate Bayesian inference in semi-mechanistic models.Statistics and computing · 2017Article
- Stochastic Simulation of Biomolecular Networks in Dynamic Environments.PLoS computational biology · 2016Article
- A Compact Model for the Complex Plant Circadian Clock.Frontiers in plant science · 2016Article
- Computational Modeling, Formal Analysis, and Tools for Systems Biology.PLoS computational biology · 2016Review
- Dynamic properties of the segmentation clock mediated by microRNA.International journal of clinical and experimental pathology · 2015Article
- Mathematical models light up plant signaling.The Plant cell · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Circadian clocks are gene regulatory networks whose role is to help the organisms to cope with variations in environmental conditions such as the day/night cycle. In this work, we explored the effects of molecular noise in single cells on the behaviour of the circadian clock in the plant model species Arabidopsis thaliana. The computational modelling language Bio-PEPA enabled us to give a stochastic interpretation of an existing deterministic model of the clock, and to easily compare the results obtained via stochastic simulation and via numerical solution of the deterministic model. First, the introduction of stochasticity in the model allowed us to estimate the unknown size of the system. Moreover, stochasticity improved the description of the available experimental data in several light conditions: noise-induced fluctuations yield a faster entrainment of the plant clock under certain photoperiods and are able to explain the experimentally observed dampening of the oscillations in plants under constant light conditions. The model predicts that the desynchronization between noisy oscillations in single cells contributes to the observed damped oscillations at the level of the cell population. Analysis of the phase, period and amplitude distributions under various light conditions demonstrated robust entrainment of the plant clock to light/dark cycles which closely matched the available experimental data.
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