ArticleNucleic acids research2011
Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Footprints in the Sno: investigating the cellular and molecular mechanisms of SNORD116.Open biology · 2025Review
- SnoRNAs: Exploring Their Implication in Human Diseases.International journal of molecular sciences · 2024Review
- The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation.Communications biology · 2023Article
- The Diagnostic Journey of a Patient with Prader-Willi-Like Syndrome and a Unique HomozygousGenes · 2021Review
- Prader-Willi syndrome: reflections on seminal studies and future therapies.Open biology · 2020Review
- Functional diversity of small nucleolar RNAs.Nucleic acids research · 2020Article
- C/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks.Non-coding RNA research · 2019Review
- RNA⁻Protein Interactions Prevent Long RNA Duplex Formation: Implications for the Design of RNA-Based Therapeutics.Molecules (Basel, Switzerland) · 2018Article
- The human MAPT locus generates circular RNAs.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Phylogenetic Analysis of the SNORD116 Locus.Genes · 2017Article
- The activity of the serotonin receptor 2C is regulated by alternative splicing.Human genetics · 2017Review
- C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake.EMBO molecular medicine · 2016Article
- SNORD116 and SNORD115 change expression of multiple genes and modify each other's activity.Gene · 2015Article
- C/D-box snoRNA-derived RNA production is associated with malignant transformation and metastatic progression in prostate cancer.Oncotarget · 2015Article
- Prader-Willi, Angelman, and 15q11-q13 Duplication Syndromes.Pediatric clinics of North America · 2015Review
- Regulatory role of small nucleolar RNAs in human diseases.BioMed research international · 2015Review
- Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.Human molecular genetics · 2014Article
- Long noncoding RNAs in imprinting and X chromosome inactivation.Biomolecules · 2014Review
- The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells.Experimental brain research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
Abstract
We describe a new method that allows cloning of double-stranded RNAs (dsRNAs) that are generated in RNase protection experiments. We demonstrate that the mouse C/D box snoRNA MBII-85 (SNORD116) is processed into at least five shorter RNAs using processing sites near known functional elements of C/D box snoRNAs. Surprisingly, the majority of cloned RNAs from RNase protection experiments were derived from endogenous cellular RNA, indicating widespread antisense expression. The cloned dsRNAs could be mapped to genome areas that show RNA expression on both DNA strands and partially overlapped with experimentally determined argonaute-binding sites. The data suggest a conserved processing pattern for some C/D box snoRNAs and abundant expression of longer, non-coding RNAs in the cell that can potentially form dsRNAs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.