Evidence map›Paper›PMID 21880527›Full record

ArticleJournal of feline medicine and surgery2011

Markers of feline leukaemia virus infection or exposure in cats from a region of low seroprevalence.

Julia A Beatty, Séverine Tasker, Oswald Jarrett, Amy Lam, Stephanie Gibson, Alice Noe-Nordberg, Angela Phillips, Anne Fawcett, Vanessa R Barrs

Open access · greenAbstract read
In one paragraph

Article in Journal of feline medicine and surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Julia A BeattyValentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia. julia.beatty@sydney.edu.au
Séverine Tasker
Oswald Jarrett
Amy Lam
Stephanie Gibson
Alice Noe-Nordberg
Angela Phillips
Anne Fawcett
Vanessa R Barrs
University of Sydney · AUConcord Repatriation General Hospital · AUUniversity of Bristol · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular techniques have demonstrated that cats may harbour feline leukaemia virus (FeLV) provirus in the absence of antigenaemia. Using quantitative real-time polymerase chain reaction (qPCR), p27 enzyme-linked immunosorbent assay (ELISA), anti-feline oncornavirus-associated cell-membrane-antigen (FOCMA) antibody testing and virus isolation (VI) we investigated three groups of cats. Among cats with cytopenias or lymphoma, 2/75 were transiently positive for provirus and anti-FOCMA antibodies were the only evidence of exposure in another. In 169 young, healthy cats, all tests were negative. In contrast, 3/4 cats from a closed household where FeLV was confirmed by isolation, had evidence of infection. Our results support a role for factors other than FeLV in the pathogenesis of cytopenias and lymphoma. There was no evidence of exposure in young cats. In regions of low prevalence, where the positive predictive value of antigen testing is low, qPCR may assist with diagnosis.

Indexed as

AnimalsBiomarkersCatsDNA, ViralEnglandFemaleLeukemia, FelineLeukemia Virus, FelineMaleReal-Time Polymerase Chain ReactionSeroepidemiologic StudiesBiomarkersDNA, Viral

Identifiers

PMID21880527
PMCPMC10832971
OpenAlexW2117467868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.