ReviewCurrent opinion in cell biology2011
Signaling circuitries controlling stem cell fate: to be or not to be.
Review in Current opinion in cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Unraveling the complexity of radiotherapy- and chemotherapy-induced oral mucositis: insights into pathogenesis and intervention strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- GPCR Screening Reveals that the Metabolite Receptor HCAR3 Regulates Epithelial Proliferation, Migration, and Cellular Respiration.The Journal of investigative dermatology · 2024Article
- Unbalanced response to growth variations reshapes the cell fate decision landscape.Nature chemical biology · 2023Article
- Analysis of the potential of human cultured nasal epithelial cell sheets to differentiate into airway epithelium.FASEB bioAdvances · 2023Article
- Towards AI-driven longevity research: An overview.Frontiers in aging · 2023Review
- Article
- The Balance between Differentiation and Terminal Differentiation Maintains Oral Epithelial Homeostasis.Cancers · 2021Review
- The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche.Stem cells (Dayton, Ohio) · 2021Article
- YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR.Journal of cellular and molecular medicine · 2021Article
- PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.Molecular biology of the cell · 2020Article
- Oral Mucositis: An Update on Innate Immunity and New Interventional Targets.Journal of dental research · 2020Review
- Unleashing Immunotherapy by Targeting Cancer Stem Cells.Cell stem cell · 2020Article
- Article
- RHO GTPases in cancer: known facts, open questions, and therapeutic challenges.Biochemical Society transactions · 2018Review
- Policing Tumorigenesis within the Skin: Good Outs Bad.Cell stem cell · 2017Article
- Article
- Rapamycin Prolongs the Survival of Corneal Epithelial Cells in Culture.Scientific reports · 2017Article
- RNAi-Based Techniques for the Analysis of Gene Function in Drosophila Germline Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer.Oncotarget · 2016Article
- Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands.Oncotarget · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The integration of extrinsic and intrinsic signals is required to preserve the self-renewal and tissue regenerative capacity of adult stem cells, while protecting them from malignant conversion or loss of proliferative potential by death, differentiation or senescence. Here we review emerging signaling circuitries regulating stem cell fate, with emphasis on epithelial stem cells. Wnt, mTOR, GPCRs, Notch, Rho GTPases, YAP and DNA and histone methylases are some of the mechanisms that allow stem cells to balance their regenerative potential and the initiation of terminal differentiation programs, guaranteeing appropriate tissue homeostasis. Understanding the signaling circuitries regulating stem cell fate decisions might provide important insights into cancer initiation and numerous human pathologies that involve the progressive loss of tissue-specific adult stem cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.