Evidence map›Paper›PMID 21880178›Full record

ArticleChinese journal of cancer2011

Platelet-derived growth factor signaling in human malignancies.

Kun-Wei Liu, Bo Hu, Shi-Yuan Cheng

Open access · bronzeAbstract readEditorial
In one paragraph

Article in Chinese journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kun-Wei LiuUniversity of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.
Bo Hu
Shi-Yuan Cheng
University of Pittsburgh · USUPMC Hillman Cancer Center · US

Funding

Modulation of Oncogenic Signaling in GlioblastomasR01CA159811 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHENG, SHI-YUAN · 2012 to 2016
$1.8M
ELMO1, Dock180 and Glioma InvasionR01CA130966 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENG, SHI-YUAN · 2008 to 2012
$1.5M
NCI NIH HHS R01 CA130966NCI NIH HHS R01 CA159811
6 · The paper itself

Abstract

Platelet-derived growth factors (PDGFs) and their receptors were identified and purified decades ago. PDGFs are important during normal development and in human cancers. In particular, autocrine PDGF signaling has been implicated in various types of malignancies such as gliomas and leukemia. In contrast, paracrine signaling was found in cancers that originate from epithelial cells, where it may be involved in stromal cell recruitment, metastasis, and epithelial-mesenchymal transition. This editorial briefly discusses autocrine and paracrine PDGF signaling and their roles in human cancers, and introduces a series of review articles in this issue that address the possible roles of PDGFs in various processes involved in different types of cancers.

Indexed as

Epithelial-Mesenchymal TransitionAnimalsAutocrine CommunicationHumansNeoplasm InvasivenessNeoplasm MetastasisNeoplasmsParacrine CommunicationPlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth FactorPlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth Factor

Identifiers

PMID21880178
PMCPMC3525704
OpenAlexW2052271129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.