ArticleBMC infectious diseases2011
Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
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- Influenza Viral Shedding in a Prospective Cohort of HIV-Infected and Uninfected Children and Adults in 2 Provinces of South Africa, 2012-2014.The Journal of infectious diseases · 2018Article
- A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients' responses to H7N9 infection.Oncotarget · 2018Article
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- Immune derangement occurs in patients with H7N9 avian influenza.Critical care (London, England) · 2014Article
- IgA level in plasma as a differential factor for influenza infection in severe viral pneumonia.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Article
- CD206+ cell number differentiates influenza A (H1N1)pdm09 from seasonal influenza A virus in fatal cases.Mediators of inflammation · 2014Article
- New molecular virus detection methods and their clinical value in lower respiratory tract infections in children.Paediatric respiratory reviews · 2013Review
- Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case.PloS one · 2013Article
- PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response.Clinical & developmental immunology · 2013Article
- Immunopathogenesis of 2009 pandemic influenza.Enfermedades infecciosas y microbiologia clinica · 2012Review
Corrections and comments
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Authors and funding
32 authors at 14 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere disease caused by 2009 pandemic influenza A/H1N1virus is characterized by the presence of hypercytokinemia. The origin of the exacerbated cytokine response is unclear. As observed previously, uncontrolled influenza virus replication could strongly influence cytokine production. The objective of the present study was to evaluate the relationship between host cytokine responses and viral levels in pandemic influenza critically ill patients.
methodsTwenty three patients admitted to the ICU with primary viral pneumonia were included in this study. A quantitative PCR based method targeting the M1 influenza gene was developed to quantify pharyngeal viral load. In addition, by using a multiplex based assay, we systematically evaluated host cytokine responses to the viral infection at admission to the ICU. Correlation studies between cytokine levels and viral load were done by calculating the Spearman correlation coefficient.
resultsFifteen patients needed of intubation and ventilation, while eight did not need of mechanical ventilation during ICU hospitalization. Viral load in pharyngeal swabs was 300 fold higher in the group of patients with the worst respiratory condition at admission to the ICU. Pharyngeal viral load directly correlated with plasma levels of the pro-inflammatory cytokines IL-6, IL-12p70, IFN-γ, the chemotactic factors MIP-1β, GM-CSF, the angiogenic mediator VEGF and also of the immuno-modulatory cytokine IL-1ra (p < 0.05). Correlation studies demonstrated also the existence of a significant positive association between the levels of these mediators, evidencing that they are simultaneously regulated in response to the virus.
conclusionsSevere respiratory disease caused by the 2009 pandemic influenza virus is characterized by the existence of a direct association between viral replication and host cytokine response, revealing a potential pathogenic link with the severe disease caused by other influenza subtypes such as H5N1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.