ArticleMolecular ecology2011
Genome-wide association analysis of clinical vs. nonclinical origin provides insights into Saccharomyces cerevisiae pathogenesis.
Article in Molecular ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- From beer to breadboards: yeast as a force for biological innovation.Genome biology · 2024Review
- Lipid saturation controls nuclear envelope function.Nature cell biology · 2023Article
- Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect inMicrobiology spectrum · 2022Article
- Extensive simulations assess the performance of genome-wide association mapping in variousPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.PLoS pathogens · 2021Article
- Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates ofFrontiers in fungal biology · 2020Article
- Baker's Yeast Clinical Isolates Provide a Model for How Pathogenic Yeasts Adapt to Stress.Trends in genetics : TIG · 2019Review
- Genome-Wide Screen forG3 (Bethesda, Md.) · 2018Article
- High-resolution mapping ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genome Sequences ofGenome announcements · 2017Article
- Using Population and Comparative Genomics to Understand the Genetic Basis of Effector-Driven Fungal Pathogen Evolution.Frontiers in plant science · 2017Review
- Bacterial Genetic Architecture of Ecological Interactions in Co-culture by GWAS-TakingFrontiers in microbiology · 2017Article
- Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation.G3 (Bethesda, Md.) · 2016Article
- Identification of Diverse Mycoviruses through Metatranscriptomics Characterization of the Viromes of Five Major Fungal Plant Pathogens.Journal of virology · 2016Article
- Use of Population Genetics to Assess the Ecology, Evolution, and Population Structure of Coccidioides.Emerging infectious diseases · 2016Article
- The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen.Genome research · 2015Article
- Saccharomyces cerevisiae: a nomadic yeast with no niche?FEMS yeast research · 2015Article
- Review
- Call for a California coccidioidomycosis consortium to face the top ten challenges posed by a recalcitrant regional disease.Mycopathologia · 2015Article
- Characterization of Cell Wall Proteins in Saccharomyces cerevisiae Clinical Isolates Elucidates Hsp150p in Virulence.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Because domesticated Saccharomyces cerevisiae strains have been used to produce fermented food and beverages for centuries without apparent health implications, S. cerevisiae has always been considered a Generally Recognized As Safe (GRAS) microorganism. However, the number of reported mucosal and systemic S. cerevisiae infections in the human population has increased and fatal infections have occurred even in relatively healthy individuals. In order to gain insight into the pathogenesis of S. cerevisiae and improve our understanding of the emergence of fungal pathogens, we performed a population-based genome-wide environmental association analysis of clinical vs. nonclinical origin in S. cerevisiae. Using tiling array-based, high-density genotypes of 44 clinical and 44 nonclinical S. cerevisiae strains from diverse geographical origins and source substrates, we identified several genetic loci associated with clinical background in S. cerevisiae. Associated polymorphisms within the coding sequences of VRP1, KIC1, SBE22 and PDR5, and the 5' upstream region of YGR146C indicate the importance of pseudohyphal formation, robust cell wall maintenance and cellular detoxification for S. cerevisiae pathogenesis, and constitute good candidates for follow-up verification of virulence and virulence-related factors underlying the pathogenicity of S. cerevisiae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.