ArticleEuropean journal of applied physiology2012
Acute metabolic responses to a 24-h ultra-marathon race in male amateur runners.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 115 citations in OpenAlex.
- Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners.Redox report : communications in free radical research · 2022Trial
- The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners.Journal of the International Society of Sports Nutrition · 2020Trial
- Trial
- Hematological and Biochemical Responses During and After a 12-h Track Ultra-Marathon Race.Journal of functional morphology and kinesiology · 2026Article
- 24-Hour Ultra-Marathon Running: A Narrative Review of Performance Factors and Physiological Impacts.Sports medicine - open · 2026Review
- Article
- Decoding Ultramarathon: Muscle Damage as the Main Impediment to Performance.Sports medicine (Auckland, N.Z.) · 2025Review
- Acid-Base and Electrolyte Balance Responses in the Performance of Female Ultramarathon Runners in a 45 km Mountain Race.Nutrients · 2025Article
- Impact of Genetic Polymorphisms on Electrochemical Parameters and Acid-Base Disorders in Brazilian Runners During a 105-Kilometer Ultramarathon.Nutrients · 2024Article
- Brainwave Patterns and Metabolic Adaptations in Rowers Crossing the Atlantic: A Case Series Pilot Study.Cureus · 2024Article
- Glycaemic Effects of a 156-km Ultra-trail Race in Athletes: An Observational Field Study.Sports medicine (Auckland, N.Z.) · 2024Observational
- Limits of Ultra: Towards an Interdisciplinary Understanding of Ultra-Endurance Running Performance.Sports medicine (Auckland, N.Z.) · 2024Review
- The Relationship between 24 h Ultramarathon Performance and the "Big Three" Strategies of Training, Nutrition, and Pacing.Sports (Basel, Switzerland) · 2022Article
- Dietary Intake of Recreational Endurance Runners Associated with Race Distance-Results from the NURMI Study (Step 2).Nutrients · 2022Article
- 768-km Multi-Stage Ultra-Trail Case Study-Muscle Damage, Biochemical Alterations and Strength Loss on Lower Limbs.International journal of environmental research and public health · 2022Article
- Muscle thickness and inflammation during a 50km ultramarathon in recreational runners.PloS one · 2022Article
- Characterizing Marathon-Induced Metabolic Changes UsingMetabolites · 2021Article
- Supplement intake in half-marathon, (ultra-)marathon and 10-km runners - results from the NURMI study (Step 2).Journal of the International Society of Sports Nutrition · 2021Article
- Do Sex Differences in Physiology Confer a Female Advantage in Ultra-Endurance Sport?Sports medicine (Auckland, N.Z.) · 2021Review
- To Be a Champion of the 24-h Ultramarathon Race. If Not the Heart ... Mosaic Theory?International journal of environmental research and public health · 2021Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study was conducted to evaluate the metabolic responses to a 24 h ultra-endurance race in male runners. Paired venous and capillary blood samples from 14 athletes (mean age 43.0 ± 10.8 years, body weight 64.3 ± 7.2 kg, VO(2max) 57.8 ± 6.1 ml kg(-1) min(-1)), taken 3 h before the run, after completing the marathon distance (42.195 km), after 12 h, and at the finish of the race, were analyzed for blood morphology, acid-base balance and electrolytes, lipid profile, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and serum enzyme activities. Mean distance covered during the race was 168.5 ± 23.1 km (range 125.2-218.5 km). Prolonged ultra-endurance exercise triggered immune and inflammatory responses, as evidenced by a twofold increase in total leukocyte count with neutrophils and monocytes as main contributors, nearly 30-fold increase in serum IL-6 and over 20-fold rise in hsCRP. A progressive exponential increase in mean creatine kinase activity up to the level 70-fold higher than the respective pre-race value, a several fold rise in serum activities of aspartate aminotransferase and alanine aminotransferase, and a fairly stable serum γ-glutamyl transferase level, were indicative of muscle, but not of liver damage. With duration of exercise, there was a progressive development of hyperventilation-induced hypocapnic alkalosis, and a marked alteration in substrate utilization towards fat oxidation to maintain blood glucose homeostasis. The results of this study may imply that progressive decline in partial CO(2) pressure (hypocapnia) that develops during prolonged exercise may contribute to increased interleukin-6 production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.