Evidence map›Paper›PMID 21878991›Full record

ReviewThe EMBO journal2011

Endosome maturation.

Jatta Huotari, Ari Helenius

Abstract readReview
In one paragraph

Review in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,302 papers.

0numbers the graph read from it
0cells of the map it votes in
1,302citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,302 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The Manipulation of Host Cells byInternational journal of molecular sciences · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

1,242 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jatta HuotariInstitute of Biochemistry, ETH Zurich, Switzerland.
Ari Helenius

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies. The maturation programme entails a dramatic transformation of these dynamic organelles disconnecting them functionally and spatially from early endosomes and preparing them for their unidirectional role as a feeder pathway to lysosomes.

Indexed as

ADP-Ribosylation Factor 1AutophagyCoat Protein Complex IEndocytosisEndosomesExosomesGTP PhosphohydrolasesHumansLysosomesrab GTP-Binding ProteinsADP-Ribosylation Factor 1Coat Protein Complex IGTP Phosphohydrolasesrab GTP-Binding Proteins

Identifiers

PMID21878991
PMCPMC3181477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.