ArticleHeredity2012
Comparison of biometrical models for joint linkage association mapping.
Article in Heredity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Article
- MAGIC populations: a next-generation framework for dissecting complex quantitative traits and accelerating molecular breeding in crops.Frontiers in plant science · 2026Review
- Comparing performances of different statistical models and multiple threshold methods in a nested association mapping population of wheat.Frontiers in plant science · 2024Article
- Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques.Frontiers in plant science · 2023Review
- Genome-wide association study as a powerful tool for dissecting competitive traits in legumes.Frontiers in plant science · 2023Review
- statgenMPP: an R package implementing an IBD-based mixed model approach for QTL mapping in a wide range of multi-parent populations.Bioinformatics (Oxford, England) · 2022Article
- Genetic diversity and population structure analysis for morphological traits in upland cotton (Gossypium hirsutum L.).Journal of applied genetics · 2022Article
- Comprehensive evaluation of mapping complex traits in wheat using genome-wide association studies.Molecular breeding : new strategies in plant improvement · 2022Review
- An IBD-based mixed model approach for QTL mapping in multiparental populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genome-wide association study in hexaploid wheat identifies novel genomic regions associated with resistance to root lesion nematode (Pratylenchus thornei).Scientific reports · 2021Article
- Intercontinental trials reveal stable QTL for Northern corn leaf blight resistance in Europe and in Brazil.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genome-wide mapping and prediction of plant architecture in a sorghum nested association mapping population.The plant genome · 2020Article
- Combination of Linkage Mapping, GWAS, and GP to Dissect the Genetic Basis of Common Rust Resistance in Tropical Maize Germplasm.International journal of molecular sciences · 2020Article
- Multi-parent multi-environment QTL analysis: an illustration with the EU-NAM Flint population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Dissecting Adaptive Traits with Nested Association Mapping: Genetic Architecture of Inflorescence Morphology in Sorghum.G3 (Bethesda, Md.) · 2020Article
- Molecular tracking of multiple disease resistance in a winter wheat diversity panel.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Genetic Dissection of Resistance to Gray Leaf Spot by Combining Genome-Wide Association, Linkage Mapping, and Genomic Prediction in Tropical Maize Germplasm.Frontiers in plant science · 2020Article
- Genetic Analysis of QTL for Resistance to Maize Lethal Necrosis in Multiple Mapping Populations.Genes · 2019Article
- Genetic architecture of maize chlorotic mottle virus and maize lethal necrosis through GWAS, linkage analysis and genomic prediction in tropical maize germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Genome-wide association of barley plant growth under drought stress using a nested association mapping population.BMC plant biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Joint linkage association mapping (JLAM) combines the advantages of linkage mapping and association mapping, and is a powerful tool to dissect the genetic architecture of complex traits. The main goal of this study was to use a cross-validation strategy, resample model averaging and empirical data analyses to compare seven different biometrical models for JLAM with regard to the correction for population structure and the quantitative trait loci (QTL) detection power. Three linear models and four linear mixed models with different approaches to control for population stratification were evaluated. Models A, B and C were linear models with either cofactors (Model-A), or cofactors and a population effect (Model-B), or a model in which the cofactors and the single-nucleotide polymorphism effect were modeled as nested within population (Model-C). The mixed models, D, E, F and G, included a random population effect (Model-D), or a random population effect with defined variance structure (Model-E), a kinship matrix defining the degree of relatedness among the genotypes (Model-F), or a kinship matrix and principal coordinates (Model-G). The tested models were conceptually different and were also found to differ in terms of power to detect QTL. Model-B with the cofactors and a population effect, effectively controlled population structure and possessed a high predictive power. The varying allele substitution effects in different populations suggest as a promising strategy for JLAM to use Model-B for the detection of QTL and then to estimate their effects by applying Model-C.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.