ReviewHeredity2012
How closely does genetic diversity in finite populations conform to predictions of neutral theory? Large deficits in regions of low recombination.
Review in Heredity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 121 citations in OpenAlex.
- Recombination Rate and Recurrent Linked Selection Shape Correlated Genomic Landscapes Across a Continuum of Divergence in Swallows.Molecular ecology · 2025Article
- The Impact of Glacial Disturbance History Upon the Genetic Diversity ofEcology and evolution · 2025Article
- Unveiling genetic variation among Bharal (Pseudois nayaur) in the Indian Himalayas using nuclear markers.Genetica · 2025Article
- Article
- Size-selective harvesting drives genomic shifts in a harvested population.Journal of fish biology · 2024Article
- Previously unmeasured genetic diversity explains part of Lewontin's paradox in abioRxiv : the preprint server for biology · 2024Article
- Directional selection, not the direction of selection, affects telomere length and copy number at ribosomal RNA loci.Scientific reports · 2024Article
- Impact of pre-copulatory sexual cannibalism on genetic diversity and efficacy of selection.Biology letters · 2024Article
- Does size-selective harvesting erode adaptive potential to thermal stress?Ecology and evolution · 2024Article
- Phenotypic diversity and provenance variation ofPeerJ · 2024Article
- Identification and biodiversity patterns ofPeerJ · 2023Article
- Extreme variation in recombination rate and genetic diversity along the Sylvioidea neo-sex chromosome.Molecular ecology · 2022Article
- Bioindicator snake shows genomic signatures of natural and anthropogenic barriers to gene flow.PloS one · 2021Article
- Long-term urbanization impacts the eastern golden frog (Evolutionary applications · 2021Article
- Conservation implications of population genetic structure in a threatened orchidPlant diversity · 2019Article
- Article
- Microsatellite DNA analysis reveals lower than expected genetic diversity in the threatened leopard cat (Prionailurus bengalensis) in South Korea.Genes & genomics · 2018Article
- Understanding and monitoring the consequences of human impacts on intraspecific variation.Evolutionary applications · 2017Review
- Extensive genetic differentiation detected within a model marsupial, the tammar wallaby (Notamacropus eugenii).PloS one · 2017Article
- Darwinism for the Genomic Age: Connecting Mutation to Diversification.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Levels of genetic diversity in finite populations are crucial in conservation and evolutionary biology. Genetic diversity is required for populations to evolve and its loss is related to inbreeding in random mating populations, and thus to reduced population fitness and increased extinction risk. Neutral theory is widely used to predict levels of genetic diversity. I review levels of genetic diversity in finite populations in relation to predictions of neutral theory. Positive associations between genetic diversity and population size, as predicted by neutral theory, are observed for microsatellites, allozymes, quantitative genetic variation and usually for mitochondrial DNA (mtDNA). However, there are frequently significant deviations from neutral theory owing to indirect selection at linked loci caused by balancing selection, selective sweeps and background selection. Substantially lower genetic diversity than predicted under neutrality was found for chromosomes with low recombination rates and high linkage disequilibrium (compared with 'normally' recombining chromosomes within species and adjusted for different copy numbers and mutation rates), including W (median 100% lower) and Y (89% lower) chromosomes, dot fourth chromosomes in Drosophila (94% lower) and mtDNA (67% lower). Further, microsatellite genetic and allelic diversity were lost at 12 and 33% faster rates than expected in populations adapting to captivity, owing to widespread selective sweeps. Overall, neither neutral theory nor most versions of the genetic draft hypothesis are compatible with all empirical results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.