ArticleNature methods2011
On target? Tracing zinc-finger-nuclease specificity.
Article in Nature methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Reshaping the Landscape of the Genome: Toolkits for Precise DNA Methylation Manipulation and Beyond.JACS Au · 2024Review
- Review
- Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate HeterodimericViruses · 2021Article
- Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers.Frontiers in endocrinology · 2021Review
- Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Review
- Direct production of XY(DMY-) sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs.Scientific reports · 2015Article
- Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals.Cellular and molecular life sciences : CMLS · 2015Review
- Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.The Biochemical journal · 2014Review
- Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.Antimicrobial agents and chemotherapy · 2014Article
- Targeted mutagenesis of Arabidopsis thaliana using engineered TAL effector nucleases.G3 (Bethesda, Md.) · 2013Article
- Zinc finger nucleases: looking toward translation.Gene therapy · 2013Review
- A novel zinc-finger nuclease platform with a sequence-specific cleavage module.Nucleic acids research · 2012Article
- Hematopoietic-stem-cell-based gene therapy for HIV disease.Cell stem cell · 2012Review
- Precision editing of large animal genomes.Advances in genetics · 2012Review
- Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein.Cardiology research and practice · 2012Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In two independent studies, researchers experimentally test the cleavage specificity of zinc-finger nucleases across the genome.
Indexed as
Identifiers
21878917What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.